Normal Tissue Toxicities
The potential differences in normal tissue toxicity between proton and photon irradiation can only be assessed by studies with a substantial amounts of clinical data due to the low frequencies of most toxicities in radiation therapy. In fact, when using clinical grading systems, such as CTCAE, variations in radiation therapy toxicity frequencies may in fact fall within the noise of patient specific radiosensitivity. In order to identify differential toxicities indicating variable biological effects, we propose to go beyond simple CTCAE grading and utilize novel approach to correlating toxicities quantified on one-dimensional (1D) blood biomarkers, two-dimensional (2D) dose-volume histogram (DVH) and normal tissue complication probability (NTCP) model biomarkers, and three-dimensional (3D) dose and imaging biomarkers.
Brain necrosis in proton therapy patients
Outcome prediction for hepatocellular carcinoma patients
FLASH radiation therapy