Publications by our Team between 2018 and 2022

1.
Predictive Modeling of Survival and Toxicity in Patients With Hepatocellular Carcinoma After Radiotherapy.
Chamseddine I, Kim Y, De B, El Naqa I, Duda DG, Wolfgang J, Pursley J, Paganetti H, Wo J, Hong T, Koay EJ, Grassberger C.
JCO Clin Cancer Inform. 2022 Feb;6:e2100169. doi: 10.1200/CCI.21.00169.
PMID: 35192402
2.
Dosimetric Modeling of Lymphopenia in Patients With Metastatic Cancer Receiving Palliative Radiation and PD-1 Immune Checkpoint Inhibitors.
Qian JM, Akama-Garren E, Shin J, Gunasti L, Bang A, Pike LRG, Grassberger C, Schoenfeld JD.
Adv Radiat Oncol. 2021 Dec 24;7(2):100880. doi: 10.1016/j.adro.2021.100880. eCollection 2022 Mar-Apr.
PMID: 35097241 Free PMC article.
3.
Spatiotemporal optimisation of prostate intensity modulated proton therapy (IMPT) treatments.
Manganaro L, Attili A, Bortfeld T, Paganetti H.
Phys Med Biol. 2022 Feb 10;67(4). doi: 10.1088/1361-6560/ac4fa2.
PMID: 35086079
4.
A dynamic blood flow model to compute absorbed dose to circulating blood and lymphocytes in liver external beam radiotherapy.
Xing S, Shin J, Pursley J, Correa-Alfonso CM, Depauw N, Domal S, Withrow J, Bolch W, Grassberger C, Paganetti H.
Phys Med Biol. 2022 Feb 15;67(4). doi: 10.1088/1361-6560/ac4da4.
PMID: 35061601
5.
Lymphocyte dynamics during and after chemo-radiation correlate to dose and outcome in stage III NSCLC patients undergoing maintenance immunotherapy.
Cho Y, Kim Y, Chamseddine I, Lee WH, Kim HR, Lee IJ, Hong MH, Cho BC, Lee CG, Cho S, Kim JS, Yoon HI, Grassberger C.
Radiother Oncol. 2022 Jan 13;168:1-7. doi: 10.1016/j.radonc.2022.01.007. Online ahead of print.
PMID: 35033601
6.
Pre- and post-treatment image-based dosimetry in90Y-microsphere radioembolization using the TOPAS Monte Carlo toolkit.
Bertolet A, Wehrenberg-Klee E, Bobić M, Grassberger C, Perl J, Paganetti H, Schuemann J.
Phys Med Biol. 2021 Dec 29;66(24):10.1088/1361-6560/ac43fd. doi: 10.1088/1361-6560/ac43fd.
PMID: 34915451
7.
CT-on-Rails Versus In-Room CBCT for Online Daily Adaptive Proton Therapy of Head-and-Neck Cancers.
Nesteruk KP, Bobić M, Lalonde A, Winey BA, Lomax AJ, Paganetti H.
Cancers (Basel). 2021 Nov 28;13(23):5991. doi: 10.3390/cancers13235991.
PMID: 34885100 Free PMC article.
8.
DNA damage modeled with Geant4-DNA: effects of plasmid DNA conformation and experimental conditions.
D-Kondo N, Moreno-Barbosa E, Štěphán V, Stefanová K, Perrot Y, Villagrasa C, Incerti S, De Celis Alonso B, Schuemann J, Faddegon B, Ramos-Méndez J.
Phys Med Biol. 2021 Dec 15;66(24). doi: 10.1088/1361-6560/ac3a22.
PMID: 34787099
9.
Mathematical Modeling to Simulate the Effect of Adding Radiation Therapy to Immunotherapy and Application to Hepatocellular Carcinoma.
Sung W, Hong TS, Poznansky MC, Paganetti H, Grassberger C.
Int J Radiat Oncol Biol Phys. 2022 Mar 15;112(4):1055-1062. doi: 10.1016/j.ijrobp.2021.11.008. Epub 2021 Nov 11.
PMID: 34774999
10.
Application of High-Z Gold Nanoparticles in Targeted Cancer Radiotherapy-Pharmacokinetic Modeling, Monte Carlo Simulation and Radiobiological Effect Modeling.
Li WB, Stangl S, Klapproth A, Shevtsov M, Hernandez A, Kimm MA, Schuemann J, Qiu R, Michalke B, Bernal MA, Li J, Hürkamp K, Zhang Y, Multhoff G.
Cancers (Basel). 2021 Oct 26;13(21):5370. doi: 10.3390/cancers13215370.
PMID: 34771534 Free PMC article.
11.
Radiation-Induced Lymphopenia Risks of Photon Versus Proton Therapy for Esophageal Cancer Patients.
Ebrahimi S, Lim G, Liu A, Lin SH, Ellsworth SG, Grassberger C, Mohan R, Cao W.
Int J Part Ther. 2021 Apr 7;8(2):17-27. doi: 10.14338/IJPT-20-00086. eCollection 2021 Fall.
PMID: 34722808 Free PMC article.
12.
Adaptive proton therapy.
Paganetti H, Botas P, Sharp GC, Winey B.
Phys Med Biol. 2021 Nov 15;66(22):10.1088/1361-6560/ac344f. doi: 10.1088/1361-6560/ac344f.
PMID: 34710858 Review.
13.
Single-Cell Profiling Reveals Metabolic Reprogramming as a Resistance Mechanism in BRAF-Mutated Multiple Myeloma.
Waldschmidt JM, Kloeber JA, Anand P, Frede J, Kokkalis A, Dimitrova V, Potdar S, Nair MS, Vijaykumar T, Im NG, Guillaumet-Adkins A, Chopra N, Stuart H, Budano L, Sotudeh N, Guo G, Grassberger C, Yee AJ, Laubach JP, Richardson PG, Anderson KC, Raje NS, Knoechel B, Lohr JG.
Clin Cancer Res. 2021 Dec 1;27(23):6432-6444. doi: 10.1158/1078-0432.CCR-21-2040. Epub 2021 Sep 13.
PMID: 34518309
14.
TOPAS-nBio validation for simulating water radiolysis and DNA damage under low-LET irradiation.
Ramos-Méndez J, LaVerne JA, Domínguez-Kondo N, Milligan J, Štěpán V, Stefanová K, Perrot Y, Villagrasa C, Shin WG, Incerti S, McNamara A, Paganetti H, Perl J, Schuemann J, Faddegon B.
Phys Med Biol. 2021 Sep 3;66(17):10.1088/1361-6560/ac1f39. doi: 10.1088/1361-6560/ac1f39.
PMID: 34412044
15.
Mechanisms and Review of Clinical Evidence of Variations in Relative Biological Effectiveness in Proton Therapy.
Paganetti H.
Int J Radiat Oncol Biol Phys. 2022 Jan 1;112(1):222-236. doi: 10.1016/j.ijrobp.2021.08.015. Epub 2021 Aug 15.
PMID: 34407443 Review.
16.
Monte Carlo methods for device simulations in radiation therapy.
Park H, Paganetti H, Schuemann J, Jia X, Min CH.
Phys Med Biol. 2021 Sep 14;66(18). doi: 10.1088/1361-6560/ac1d1f.
PMID: 34384063 Review.
17.
HEDOS-a computational tool to assess radiation dose to circulating blood cells during external beam radiotherapy based on whole-body blood flow simulations.
Shin J, Xing S, McCullum L, Hammi A, Pursley J, Correa CA, Withrow J, Domal S, Bolch W, Paganetti H, Grassberger C.
Phys Med Biol. 2021 Aug 3;66(16):10.1088/1361-6560/ac16ea. doi: 10.1088/1361-6560/ac16ea.
PMID: 34293735
18.
The Biological Basis for Enhanced Effects of Proton Radiation Therapy Relative to Photon Radiation Therapy for Head and Neck Squamous Cell Carcinoma.
Wang L, Fossati P, Paganetti H, Ma L, Gillison M, Myers JN, Hug E, Frank SJ.
Int J Part Ther. 2021 Jun 25;8(1):3-13. doi: 10.14338/IJPT-20-00070.1. eCollection 2021 Summer.
PMID: 34285931 Free PMC article.
19.
Proton vs. photon radiotherapy for MR-guided dose escalation of intraprostatic lesions.
Moteabbed M, Harisinghani M, Paganetti H, Trofimov A, Lu HM, Efstathiou JA.
Acta Oncol. 2021 Oct;60(10):1283-1290. doi: 10.1080/0284186X.2021.1947523. Epub 2021 Jul 20.
PMID: 34282708
20.
The relation between microdosimetry and induction of direct damage to DNA by alpha particles.
Bertolet A, Ramos-Méndez J, Paganetti H, Schuemann J.
Phys Med Biol. 2021 Jul 30;66(15):10.1088/1361-6560/ac15a5. doi: 10.1088/1361-6560/ac15a5.
PMID: 34280910
21.
Modelling treatment-response rates.
Grassberger C, Ngwa W.
Nat Biomed Eng. 2021 Apr;5(4):295-296. doi: 10.1038/s41551-021-00717-w.
PMID: 33864036 Free PMC article.
22.
Intercomparison of Monte Carlo calculated dose enhancement ratios for gold nanoparticles irradiated by X-rays: Assessing the uncertainty and correct methodology for extended beams.
Rabus H, Li WB, Villagrasa C, Schuemann J, Hepperle PA, de la Fuente Rosales L, Beuve M, Di Maria S, Klapproth AP, Li CY, Poignant F, Rudek B, Nettelbeck H.
Phys Med. 2021 Apr;84:241-253. doi: 10.1016/j.ejmp.2021.03.005. Epub 2021 Mar 23.
PMID: 33766478
23.
Anatomic changes in head and neck intensity-modulated proton therapy: Comparison between robust optimization and online adaptation.
Lalonde A, Bobić M, Winey B, Verburg J, Sharp GC, Paganetti H.
Radiother Oncol. 2021 Jun;159:39-47. doi: 10.1016/j.radonc.2021.03.008. Epub 2021 Mar 17.
PMID: 33741469
24.
Radiation-Associated Lymphopenia and Outcomes of Patients with Unresectable Hepatocellular Carcinoma Treated with Radiotherapy.
De B, Ng SP, Liu AY, Avila S, Tao R, Holliday EB, Brownlee Z, Kaseb A, Lee S, Raghav K, Vauthey JN, Minsky BD, Herman JM, Das P, Smith GL, Taniguchi CM, Krishnan S, Crane CH, Grassberger C, Hong TS, Lin SH, Koong AC, Mohan R, Koay EJ.
J Hepatocell Carcinoma. 2021 Mar 3;8:57-69. doi: 10.2147/JHC.S282062. eCollection 2021.
PMID: 33688489 Free PMC article.
25.
Physics of Particle Beam and Hypofractionated Beam Delivery in NSCLC.
Paganetti H, Grassberger C, Sharp GC.
Semin Radiat Oncol. 2021 Apr;31(2):162-169. doi: 10.1016/j.semradonc.2020.11.004.
PMID: 33610274 Review.
26.
Brain-Specific Relative Biological Effectiveness of Protons Based on Long-term Outcome of Patients With Nasopharyngeal Carcinoma.
Zhang YY, Huo WL, Goldberg SI, Slater JM, Adams JA, Deng XW, Sun Y, Ma J, Fullerton BC, Paganetti H, Loeffler JS, Lu HM, Chan AW.
Int J Radiat Oncol Biol Phys. 2021 Jul 15;110(4):984-992. doi: 10.1016/j.ijrobp.2021.02.018. Epub 2021 Feb 16.
PMID: 33600889 Clinical Trial.
27.
Targeting the DNA replication stress phenotype of KRAS mutant cancer cells.
Al Zubaidi T, Gehrisch OHF, Genois MM, Liu Q, Lu S, Kung J, Xie Y, Schuemann J, Lu HM, Hata AN, Zou L, Borgmann K, Willers H.
Sci Rep. 2021 Feb 11;11(1):3656. doi: 10.1038/s41598-021-83142-y.
PMID: 33574444 Free PMC article.
28.
Circulating Lymphocyte Counts Early During Radiation Therapy Are Associated With Recurrence in Pediatric Medulloblastoma.
Grassberger C, Shinnick D, Yeap BY, Tracy M, G Ellsworth S, Hess CB, Weyman EA, Gallotto SL, Lawell MP, Bajaj B, Ebb DH, Ioakeim-Ioannidou M, Loeffler JS, MacDonald SM, Tarbell NJ, Yock TI.
Int J Radiat Oncol Biol Phys. 2021 Jul 15;110(4):1044-1052. doi: 10.1016/j.ijrobp.2021.01.035. Epub 2021 Feb 5.
PMID: 33556478
29.
The impact of variable relative biological effectiveness in proton therapy for left-sided breast cancer when estimating normal tissue complications in the heart and lung.
Marteinsdottir M, Wang CC, McNamara A, Depauw N, Shin J, Paganetti H.
Phys Med Biol. 2021 Jan 30;66(3):035023. doi: 10.1088/1361-6560/abd230.
PMID: 33522498
30.
Comparison of weekly and daily online adaptation for head and neck intensity-modulated proton therapy.
Bobić M, Lalonde A, Sharp GC, Grassberger C, Verburg JM, Winey BA, Lomax AJ, Paganetti H.
Phys Med Biol. 2021 Feb 25;66(5):10.1088/1361-6560/abe050. doi: 10.1088/1361-6560/abe050.
PMID: 33503592 Free PMC article.
31.
A Multi-institutional Comparative Analysis of Proton and Photon Therapy-Induced Hematologic Toxicity in Patients With Medulloblastoma.
Liu KX, Ioakeim-Ioannidou M, Susko MS, Rao AD, Yeap BY, Snijders AM, Ladra MM, Vogel J, Zaslowe-Dude C, Marcus KJ, Yock TI, Grassberger C, Braunstein SE, Haas-Kogan DA, Terezakis SA, MacDonald SM.
Int J Radiat Oncol Biol Phys. 2021 Mar 1;109(3):726-735. doi: 10.1016/j.ijrobp.2020.09.049. Epub 2020 Nov 23.
PMID: 33243479
32.
Roadmap: proton therapy physics and biology.
Paganetti H, Beltran C, Both S, Dong L, Flanz J, Furutani K, Grassberger C, Grosshans DR, Knopf AC, Langendijk JA, Nystrom H, Parodi K, Raaymakers BW, Richter C, Sawakuchi GO, Schippers M, Shaitelman SF, Teo BKK, Unkelbach J, Wohlfahrt P, Lomax T.
Phys Med Biol. 2021 Feb 26;66(5). doi: 10.1088/1361-6560/abcd16.
PMID: 33227715 Review.
33.
“Cancer risk after breast proton therapy considering physiological and radiobiological uncertainties” by Raptis et al. (Physica Medica 76 (2020) 1-6).
Paganetti H.
Phys Med. 2020 Dec;80:274-276. doi: 10.1016/j.ejmp.2020.11.008. Epub 2020 Nov 20.
PMID: 33227626
34.
FLASH Investigations Using Protons: Design of Delivery System, Preclinical Setup and Confirmation of FLASH Effect with Protons in Animal Systems.
Zhang Q, Cascio E, Li C, Yang Q, Gerweck LE, Huang P, Gottschalk B, Flanz J, Schuemann J.
Radiat Res. 2020 Dec 1;194(6):656-664. doi: 10.1667/RADE-20-00068.1.
PMID: 32991708
35.
Brain Necrosis in Adult Patients After Proton Therapy: Is There Evidence for Dependency on Linear Energy Transfer?
Niemierko A, Schuemann J, Niyazi M, Giantsoudi D, Maquilan G, Shih HA, Paganetti H.
Int J Radiat Oncol Biol Phys. 2021 Jan 1;109(1):109-119. doi: 10.1016/j.ijrobp.2020.08.058. Epub 2020 Sep 7.
PMID: 32911019 Free PMC article.
36.
Challenges in the quantification approach to a radiation relevant adverse outcome pathway for lung cancer.
Stainforth R, Schuemann J, McNamara AL, Wilkins RC, Chauhan V.
Int J Radiat Biol. 2021;97(1):85-101. doi: 10.1080/09553002.2020.1820096. Epub 2020 Sep 30.
PMID: 32909875 Free PMC article.
37.
Modeling Resistance and Recurrence Patterns of Combined Targeted-Chemoradiotherapy Predicts Benefit of Shorter Induction Period.
McClatchy DM, Willers H, Hata AN, Piotrowska Z, Sequist LV, Paganetti H, Grassberger C.
Cancer Res. 2020 Nov 15;80(22):5121-5133. doi: 10.1158/0008-5472.CAN-19-3883. Epub 2020 Sep 9.
PMID: 32907839 Free PMC article.
38.
LET-Dependent Intertrack Yields in Proton Irradiation at Ultra-High Dose Rates Relevant for FLASH Therapy.
Ramos-Méndez J, Domínguez-Kondo N, Schuemann J, McNamara A, Moreno-Barbosa E, Faddegon B.
Radiat Res. 2020 Oct 2;194(4):351-362. doi: 10.1667/RADE-20-00084.1.
PMID: 32857855 Free PMC article.
39.
Proton therapy reduces the likelihood of high-grade radiation-induced lymphopenia in glioblastoma patients: phase II randomized study of protons vs photons.
Mohan R, Liu AY, Brown PD, Mahajan A, Dinh J, Chung C, McAvoy S, McAleer MF, Lin SH, Li J, Ghia AJ, Zhu C, Sulman EP, de Groot JF, Heimberger AB, McGovern SL, Grassberger C, Shih H, Ellsworth S, Grosshans DR.
Neuro Oncol. 2021 Feb 25;23(2):284-294. doi: 10.1093/neuonc/noaa182.
PMID: 32750703 Free PMC article. Clinical Trial.
40.
Prolongation of radiotherapy duration is associated with inferior overall survival in patients with pediatric medulloblastoma and central nervous system primitive neuroectodermal tumors.
Baliga S, Bajaj BVM, Kabarriti R, Grassberger C, Patteson B, Yeap B, Fox JL, Garg MK, Yock TI.
Pediatr Blood Cancer. 2020 Oct;67(10):e28558. doi: 10.1002/pbc.28558. Epub 2020 Jul 25.
PMID: 32710698
41.
A tumor-immune interaction model for hepatocellular carcinoma based on measured lymphocyte counts in patients undergoing radiotherapy.
Sung W, Grassberger C, McNamara AL, Basler L, Ehrbar S, Tanadini-Lang S, Hong TS, Paganetti H.
Radiother Oncol. 2020 Oct;151:73-81. doi: 10.1016/j.radonc.2020.07.025. Epub 2020 Jul 15.
PMID: 32679308 Free PMC article.
42.
Evaluation of CBCT scatter correction using deep convolutional neural networks for head and neck adaptive proton therapy.
Lalonde A, Winey B, Verburg J, Paganetti H, Sharp GC.
Phys Med Biol. 2020 Dec 4;65(24):10.1088/1361-6560/ab9fcb. doi: 10.1088/1361-6560/ab9fcb.
PMID: 32580174 Free PMC article.
43.
The risk for developing a secondary cancer after breast radiation therapy: Comparison of photon and proton techniques.
Paganetti H, Depauw N, Johnson A, Forman RB, Lau J, Jimenez R.
Radiother Oncol. 2020 Aug;149:212-218. doi: 10.1016/j.radonc.2020.05.035. Epub 2020 May 25.
PMID: 32464163
44.
Assessing second cancer risk after primary cancer treatment with photon or proton radiotherapy.
DeLaney TF, Yock TI, Paganetti H.
Cancer. 2020 Aug 1;126(15):3397-3399. doi: 10.1002/cncr.32936. Epub 2020 May 19.
PMID: 32426850 No abstract available.
45.
Optimizing Radiation Therapy to Boost Systemic Immune Responses in Breast Cancer: A Critical Review for Breast Radiation Oncologists.
Ho AY, Wright JL, Blitzblau RC, Mutter RW, Duda DG, Norton L, Bardia A, Spring L, Isakoff SJ, Chen JH, Grassberger C, Bellon JR, Beriwal S, Khan AJ, Speers C, Dunn SA, Thompson A, Santa-Maria CA, Krop IE, Mittendorf E, King TA, Gupta GP.
Int J Radiat Oncol Biol Phys. 2020 Sep 1;108(1):227-241. doi: 10.1016/j.ijrobp.2020.05.011. Epub 2020 May 14.
PMID: 32417409 Free PMC article. Review.
46.
Cellular Response to Proton Irradiation: A Simulation Study with TOPAS-nBio.
Zhu H, McNamara AL, McMahon SJ, Ramos-Mendez J, Henthorn NT, Faddegon B, Held KD, Perl J, Li J, Paganetti H, Schuemann J.
Radiat Res. 2020 Jul 8;194(1):9-21. doi: 10.1667/RR15531.1.
PMID: 32401689 Free PMC article.
47.
DICOM-RT Ion interface to utilize MC simulations in routine clinical workflow for proton pencil beam radiotherapy.
Shin J, Kooy HM, Paganetti H, Clasie B.
Phys Med. 2020 Jun;74:1-10. doi: 10.1016/j.ejmp.2020.04.018. Epub 2020 May 7.
PMID: 32388464 Free PMC article.
48.
Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions.
Schuemann J, Bagley AF, Berbeco R, Bromma K, Butterworth KT, Byrne HL, Chithrani BD, Cho SH, Cook JR, Favaudon V, Gholami YH, Gargioni E, Hainfeld JF, Hespeels F, Heuskin AC, Ibeh UM, Kuncic Z, Kunjachan S, Lacombe S, Lucas S, Lux F, McMahon S, Nevozhay D, Ngwa W, Payne JD, Penninckx S, Porcel E, Prise KM, Rabus H, Ridwan SM, Rudek B, Sanche L, Singh B, Smilowitz HM, Sokolov KV, Sridhar S, Stanishevskiy Y, Sung W, Tillement O, Virani N, Yantasee W, Krishnan S.
Phys Med Biol. 2020 Oct 22;65(21):21RM02. doi: 10.1088/1361-6560/ab9159.
PMID: 32380492 Review.
49.
Dosimetric Analysis and Normal-Tissue Complication Probability Modeling of Child-Pugh Score and Albumin-Bilirubin Grade Increase After Hepatic Irradiation.
Pursley J, El Naqa I, Sanford NN, Noe B, Wo JY, Eyler CE, Hwang M, Brock KK, Yeap BY, Wolfgang JA, Hong TS, Grassberger C.
Int J Radiat Oncol Biol Phys. 2020 Aug 1;107(5):986-995. doi: 10.1016/j.ijrobp.2020.04.027. Epub 2020 Apr 27.
PMID: 32353390 Free PMC article.
50.
The TOPAS tool for particle simulation, a Monte Carlo simulation tool for physics, biology and clinical research.
Faddegon B, Ramos-Méndez J, Schuemann J, McNamara A, Shin J, Perl J, Paganetti H.
Phys Med. 2020 Apr;72:114-121. doi: 10.1016/j.ejmp.2020.03.019. Epub 2020 Apr 3.
PMID: 32247964 Free PMC article.
51.
End-of-Range Radiobiological Effect on Rib Fractures in Patients Receiving Proton Therapy for Breast Cancer.
Wang CC, McNamara AL, Shin J, Schuemann J, Grassberger C, Taghian AG, Jimenez RB, MacDonald SM, Paganetti H.
Int J Radiat Oncol Biol Phys. 2020 Jul 1;107(3):449-454. doi: 10.1016/j.ijrobp.2020.03.012. Epub 2020 Mar 30.
PMID: 32240774 Free PMC article.
52.
Perspectives on the model-based approach to proton therapy trials: A retrospective study of a lung cancer randomized trial.
McNamara AL, Hall DC, Shusharina N, Liu A, Wei X, Ajdari A, Mohan R, Liao Z, Paganetti H.
Radiother Oncol. 2020 Jun;147:8-14. doi: 10.1016/j.radonc.2020.02.022. Epub 2020 Mar 27.
PMID: 32224318 Free PMC article. Clinical Trial.
53.
Modeling RBE-weighted dose variations in irregularly moving abdominal targets treated with carbon ion beams.
Meschini G, Kamp F, Hofmaier J, Reiner M, Sharp G, Paganetti H, Belka C, Wilkens JJ, Carlson DJ, Parodi K, Baroni G, Riboldi M.
Med Phys. 2020 Jul;47(7):2768-2778. doi: 10.1002/mp.14135. Epub 2020 Apr 18.
PMID: 32162332
54.
4D blood flow model for dose calculation to circulating blood and lymphocytes.
Hammi A, Paganetti H, Grassberger C.
Phys Med Biol. 2020 Mar 2;65(5):055008. doi: 10.1088/1361-6560/ab6c41.
PMID: 32119649 Free PMC article.
55.
A parameter sensitivity study for simulating DNA damage after proton irradiation using TOPAS-nBio.
Zhu H, McNamara AL, Ramos-Mendez J, McMahon SJ, Henthorn NT, Faddegon B, Held KD, Perl J, Li J, Paganetti H, Schuemann J.
Phys Med Biol. 2020 Apr 23;65(8):085015. doi: 10.1088/1361-6560/ab7a6b.
PMID: 32101803 Free PMC article.
56.
Intercomparison of dose enhancement ratio and secondary electron spectra for gold nanoparticles irradiated by X-rays calculated using multiple Monte Carlo simulation codes.
Li WB, Belchior A, Beuve M, Chen YZ, Di Maria S, Friedland W, Gervais B, Heide B, Hocine N, Ipatov A, Klapproth AP, Li CY, Li JL, Multhoff G, Poignant F, Qiu R, Rabus H, Rudek B, Schuemann J, Stangl S, Testa E, Villagrasa C, Xie WZ, Zhang YB.
Phys Med. 2020 Jan;69:147-163. doi: 10.1016/j.ejmp.2019.12.011. Epub 2020 Jan 6.
PMID: 31918367 Free PMC article.
57.
Modulation of nanoparticle uptake, intracellular distribution, and retention with docetaxel to enhance radiotherapy.
Bannister AH, Bromma K, Sung W, Monica M, Cicon L, Howard P, Chow RL, Schuemann J, Chithrani DB.
Br J Radiol. 2020 Feb 1;93(1106):20190742. doi: 10.1259/bjr.20190742. Epub 2019 Dec 12.
PMID: 31778316 Free PMC article.
58.
Comparing 2 Monte Carlo Systems in Use for Proton Therapy Research.
Newpower M, Schuemann J, Mohan R, Paganetti H, Titt U.
Int J Part Ther. 2019 Summer;6(1):18-27. doi: 10.14338/IJPT-18-00043.1. Epub 2019 May 3.
PMID: 31773045 Free PMC article.
59.
Modelling variable proton relative biological effectiveness for treatment planning.
McNamara A L, Willers H, Paganetti H.
Br J Radiol. 2020 Mar;93(1107):20190334. doi: 10.1259/bjr.20190334. Epub 2019 Nov 18.
PMID: 31738081 Free PMC article. Review.
60.
Pragmatic randomised clinical trial of proton versus photon therapy for patients with non-metastatic breast cancer: the Radiotherapy Comparative Effectiveness (RadComp) Consortium trial protocol.
Bekelman JE, Lu H, Pugh S, Baker K, Berg CD, Berrington de González A, Braunstein LZ, Bosch W, Chauhan C, Ellenberg S, Fang LC, Freedman GM, Hahn EA, Haffty BG, Khan AJ, Jimenez RB, Kesslering C, Ky B, Lee C, Lu HM, Mishra MV, Mullins CD, Mutter RW, Nagda S, Pankuch M, Powell SN, Prior FW, Schupak K, Taghian AG, Wilkinson JB, MacDonald SM, Cahlon O; RadComp (Radiotherapy Comparative Effectiveness Consortium).
BMJ Open. 2019 Oct 15;9(10):e025556. doi: 10.1136/bmjopen-2018-025556.
PMID: 31619413 Free PMC article.
61.
A dual-stream deep convolutional network for reducing metal streak artifacts in CT images.
Gjesteby L, Shan H, Yang Q, Xi Y, Jin Y, Giantsoudi D, Paganetti H, De Man B, Wang G.
Phys Med Biol. 2019 Nov 26;64(23):235003. doi: 10.1088/1361-6560/ab4e3e.
PMID: 31618724
62.
Three discipline collaborative radiation therapy (3DCRT) special debate: The single most important factor in determining the future of SBRT is immune response.
Grassberger C, Huber K, Jacob NK, Green MD, Mahler P, Prisciandaro J, Dominello M, Joiner MC, Burmeister J.
J Appl Clin Med Phys. 2019 Oct;20(10):6-12. doi: 10.1002/acm2.12728. Epub 2019 Oct 1.
PMID: 31573143 Free PMC article. No abstract available.
63.
Volumetric and actuarial analysis of brain necrosis in proton therapy using a novel mixture cure model.
Niyazi M, Niemierko A, Paganetti H, Söhn M, Schapira E, Goldberg S, Adams J, Kim V, Oh KS, Hwang WL, Lu HM, Belka C, Busse PM, Loeffler JS, Shih HA.
Radiother Oncol. 2020 Jan;142:154-161. doi: 10.1016/j.radonc.2019.09.008. Epub 2019 Sep 25.
PMID: 31563411
64.
A review on cathode materials for advanced lithium ion batteries: microstructure designs and performance regulations.
Chen Z, Zhang W, Yang Z.
Nanotechnology. 2020 Jan 3;31(1):012001. doi: 10.1088/1361-6528/ab4447. Epub 2019 Sep 13.
PMID: 31519017
65.
Impact of uncertainties in range and RBE on small field proton therapy.
Marteinsdottir M, Schuemann J, Paganetti H.
Phys Med Biol. 2019 Oct 10;64(20):205005. doi: 10.1088/1361-6560/ab448f.
PMID: 31519016
66.
Monte Carlo Processing on a Chip (MCoaC)-preliminary experiments toward the realization of optimal-hardware for TOPAS/Geant4 to drive discovery.
Abhyankar YS, Dev S, Sarun OS, Saxena A, Joshi R, Darbari H, Sajish C, Sonavane UB, Gavane V, Deshpande A, Dixit T, Harsh R, Badwe R, Rath GK, Laskar S, Faddegon B, Perl J, Paganetti H, Schuemann J, Srivastava A, Obcemea C, Nath AK, Sharma A, Buchsbaum J.
Phys Med. 2019 Aug;64:166-173. doi: 10.1016/j.ejmp.2019.06.016. Epub 2019 Jul 16.
PMID: 31515016 Free PMC article.
67.
Radio-enhancement by gold nanoparticles and their impact on water radiolysis for x-ray, proton and carbon-ion beams.
Rudek B, McNamara A, Ramos-Méndez J, Byrne H, Kuncic Z, Schuemann J.
Phys Med Biol. 2019 Aug 28;64(17):175005. doi: 10.1088/1361-6560/ab314c.
PMID: 31295730
68.
Assessing the interactions between radiotherapy and antitumour immunity.
Grassberger C, Ellsworth SG, Wilks MQ, Keane FK, Loeffler JS.
Nat Rev Clin Oncol. 2019 Dec;16(12):729-745. doi: 10.1038/s41571-019-0238-9. Epub 2019 Jun 26.
PMID: 31243334 Review.
69.
Modulation of gold nanoparticle mediated radiation dose enhancement through synchronization of breast tumor cell population.
Rieck K, Bromma K, Sung W, Bannister A, Schuemann J, Chithrani DB.
Br J Radiol. 2019 Aug;92(1100):20190283. doi: 10.1259/bjr.20190283. Epub 2019 Jul 2.
PMID: 31219711 Free PMC article.
70.
Validation of a model for physical dose variations in irregularly moving targets treated with carbon ion beams.
Meschini G, Seregni M, Molinelli S, Vai A, Phillips J, Sharp GC, Pella A, Valvo F, Ciocca M, Riboldi M, Paganetti H, Baroni G.
Med Phys. 2019 Aug;46(8):3663-3673. doi: 10.1002/mp.13662. Epub 2019 Jul 8.
PMID: 31206718
71.
The microdosimetric extension in TOPAS: development and comparison with published data.
Zhu H, Chen Y, Sung W, McNamara AL, Tran LT, Burigo LN, Rosenfeld AB, Li J, Faddegon B, Schuemann J, Paganetti H.
Phys Med Biol. 2019 Jul 11;64(14):145004. doi: 10.1088/1361-6560/ab23a3.
PMID: 31117056 Free PMC article.
72.
Patient-Specific Tumor Growth Trajectories Determine Persistent and Resistant Cancer Cell Populations during Treatment with Targeted Therapies.
Grassberger C, McClatchy D 3rd, Geng C, Kamran SC, Fintelmann F, Maruvka YE, Piotrowska Z, Willers H, Sequist LV, Hata AN, Paganetti H.
Cancer Res. 2019 Jul 15;79(14):3776-3788. doi: 10.1158/0008-5472.CAN-18-3652. Epub 2019 May 21.
PMID: 31113818 Free PMC article.
73.
Applying a variable relative biological effectiveness (RBE) might affect the analysis of clinical trials comparing photon and proton therapy for prostate cancer.
Marteinsdottir M, Paganetti H.
Phys Med Biol. 2019 Jun 5;64(11):115027. doi: 10.1088/1361-6560/ab2144.
PMID: 31082810
74.
Differential inflammatory response dynamics in normal lung following stereotactic body radiation therapy with protons versus photons.
Li Y, Dykstra M, Best TD, Pursley J, Chopra N, Keane FK, Khandekar MJ, Sharp GC, Paganetti H, Willers H, Fintelmann FJ, Grassberger C.
Radiother Oncol. 2019 Jul;136:169-175. doi: 10.1016/j.radonc.2019.04.004. Epub 2019 Apr 20.
PMID: 31015121 Free PMC article.
75.
Predicting In Vitro Cancer Cell Survival Based on Measurable Cell Characteristics.
Oesten H, Neubeck CV, Jakob A, Enghardt W, Krause M, McMahon SJ, Grassberger C, Paganetti H, Lühr A.
Radiat Res. 2019 Jun;191(6):532-544. doi: 10.1667/RR15265.1. Epub 2019 Apr 22.
PMID: 31008688
76.
Protons versus Photons for Unresectable Hepatocellular Carcinoma: Liver Decompensation and Overall Survival.
Sanford NN, Pursley J, Noe B, Yeap BY, Goyal L, Clark JW, Allen JN, Blaszkowsky LS, Ryan DP, Ferrone CR, Tanabe KK, Qadan M, Crane CH, Koay EJ, Eyler C, DeLaney TF, Zhu AX, Wo JY, Grassberger C, Hong TS.
Int J Radiat Oncol Biol Phys. 2019 Sep 1;105(1):64-72. doi: 10.1016/j.ijrobp.2019.01.076. Epub 2019 Jan 23.
PMID: 30684667
77.
Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy.
Paganetti H, Blakely E, Carabe-Fernandez A, Carlson DJ, Das IJ, Dong L, Grosshans D, Held KD, Mohan R, Moiseenko V, Niemierko A, Stewart RD, Willers H.
Med Phys. 2019 Mar;46(3):e53-e78. doi: 10.1002/mp.13390. Epub 2019 Feb 14.
PMID: 30661238
78.
TOPAS-nBio: An Extension to the TOPAS Simulation Toolkit for Cellular and Sub-cellular Radiobiology.
Schuemann J, McNamara AL, Ramos-Méndez J, Perl J, Held KD, Paganetti H, Incerti S, Faddegon B.
Radiat Res. 2019 Feb;191(2):125-138. doi: 10.1667/RR15226.1. Epub 2019 Jan 4.
PMID: 30609382 Free PMC article.
79.
Online adaption approaches for intensity modulated proton therapy for head and neck patients based on cone beam CTs and Monte Carlo simulations.
Botas P, Kim J, Winey B, Paganetti H.
Phys Med Biol. 2018 Dec 19;64(1):015004. doi: 10.1088/1361-6560/aaf30b.
PMID: 30524097
80.
Report of a National Cancer Institute special panel: Characterization of the physical parameters of particle beams for biological research.
Durante M, Paganetti H, Pompos A, Kry SF, Wu X, Grosshans DR.
Med Phys. 2019 Feb;46(2):e37-e52. doi: 10.1002/mp.13324. Epub 2018 Dec 31.
PMID: 30506898
81.
Computational models and tools.
Schuemann J, Bassler N, Inaniwa T.
Med Phys. 2018 Nov;45(11):e1073-e1085. doi: 10.1002/mp.12521.
PMID: 30421814 Review.
82.
LET-weighted doses effectively reduce biological variability in proton radiotherapy planning.
McMahon SJ, Paganetti H, Prise KM.
Phys Med Biol. 2018 Nov 9;63(22):225009. doi: 10.1088/1361-6560/aae8a5.
PMID: 30412471
83.
A New Standard DNA Damage (SDD) Data Format.
Schuemann J, McNamara AL, Warmenhoven JW, Henthorn NT, Kirkby KJ, Merchant MJ, Ingram S, Paganetti H, Held KD, Ramos-Mendez J, Faddegon B, Perl J, Goodhead DT, Plante I, Rabus H, Nettelbeck H, Friedland W, Kundrát P, Ottolenghi A, Baiocco G, Barbieri S, Dingfelder M, Incerti S, Villagrasa C, Bueno M, Bernal MA, Guatelli S, Sakata D, Brown JMC, Francis Z, Kyriakou I, Lampe N, Ballarini F, Carante MP, Davídková M, Štěpán V, Jia X, Cucinotta FA, Schulte R, Stewart RD, Carlson DJ, Galer S, Kuncic Z, Lacombe S, Milligan J, Cho SH, Sawakuchi G, Inaniwa T, Sato T, Li W, Solov’yov AV, Surdutovich E, Durante M, Prise KM, McMahon SJ.
Radiat Res. 2019 Jan;191(1):76-92. doi: 10.1667/RR15209.1. Epub 2018 Nov 8.
PMID: 30407901 Free PMC article.
84.
Pretreatment plasma HGF as potential biomarker for susceptibility to radiation-induced liver dysfunction after radiotherapy.
Hong TS, Grassberger C, Yeap BY, Jiang W, Wo JY, Goyal L, Clark JW, Crane CH, Koay EJ, Dima S, Eyler CE, Popescu I, DeLaney TF, Zhu AX, Duda DG.
NPJ Precis Oncol. 2018 Oct 18;2:22. doi: 10.1038/s41698-018-0065-y. eCollection 2018.
PMID: 30374460 Free PMC article.
85.
Proton Relative Biological Effectiveness – Uncertainties and Opportunities.
Paganetti H.
Int J Part Ther. 2018 Summer;5(1):2-14. doi: 10.14338/IJPT-18-00011.1. Epub 2018 Sep 21.
PMID: 30370315 Free PMC article.
86.
Validation of Effective Dose as a Better Predictor of Radiation Pneumonitis Risk Than Mean Lung Dose: Secondary Analysis of a Randomized Trial.
Tucker SL, Xu T, Paganetti H, Deist T, Verma V, Choi N, Mohan R, Liao Z.
Int J Radiat Oncol Biol Phys. 2019 Feb 1;103(2):403-410. doi: 10.1016/j.ijrobp.2018.09.029. Epub 2018 Oct 3.
PMID: 30291994 Clinical Trial.
87.
Impact of potentially variable RBE in liver proton therapy.
Chen Y, Grassberger C, Li J, Hong TS, Paganetti H.
Phys Med Biol. 2018 Sep 21;63(19):195001. doi: 10.1088/1361-6560/aadf24.
PMID: 30183674 Free PMC article.
88.
Computational Modeling and Clonogenic Assay for Radioenhancement of Gold Nanoparticles Using 3D Live Cell Images.
Sung W, Jeong Y, Kim H, Jeong H, Grassberger C, Jung S, Ahn GO, Kim IH, Schuemann J, Lee K, Ye SJ.
Radiat Res. 2018 Nov;190(5):558-564. doi: 10.1667/RR15134.1. Epub 2018 Aug 24.
PMID: 30142031 Free PMC article.
89.
Author Correction: Prediction of Treatment Response for Combined Chemo- and Radiation Therapy for Non-Small Cell Lung Cancer Patients Using a Bio-Mathematical Model.
Geng C, Paganetti H, Grassberger C.
Sci Rep. 2018 Aug 17;8(1):12631. doi: 10.1038/s41598-018-30761-7.
PMID: 30115991 Free PMC article.
90.
Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit.
McNamara AL, Ramos-Méndez J, Perl J, Held K, Dominguez N, Moreno E, Henthorn NT, Kirkby KJ, Meylan S, Villagrasa C, Incerti S, Faddegon B, Paganetti H, Schuemann J.
Phys Med Biol. 2018 Sep 6;63(17):175018. doi: 10.1088/1361-6560/aad8eb.
PMID: 30088810 Free PMC article.
91.
Asymptomatic Late-phase Radiographic Changes Among Chest-Wall Patients Are Associated With a Proton RBE Exceeding 1.1.
Underwood TSA, Grassberger C, Bass R, MacDonald SM, Meyersohn NM, Yeap BY, Jimenez RB, Paganetti H.
Int J Radiat Oncol Biol Phys. 2018 Jul 15;101(4):809-819. doi: 10.1016/j.ijrobp.2018.03.037. Epub 2018 Apr 17.
PMID: 29976493
92.
Relative Biological Effectiveness Uncertainties and Implications for Beam Arrangements and Dose Constraints in Proton Therapy.
Paganetti H, Giantsoudi D.
Semin Radiat Oncol. 2018 Jun;28(3):256-263. doi: 10.1016/j.semradonc.2018.02.010.
PMID: 29933885 Review.
93.
Considerations when treating lung cancer with passive scatter or active scanning proton therapy.
St James S, Grassberger C, Lu HM.
Transl Lung Cancer Res. 2018 Apr;7(2):210-215. doi: 10.21037/tlcr.2018.04.01.
PMID: 29876321 Free PMC article. Review.
94.
Energy optimization in gold nanoparticle enhanced radiation therapy.
Sung W, Schuemann J.
Phys Med Biol. 2018 Jun 25;63(13):135001. doi: 10.1088/1361-6560/aacab6.
PMID: 29873303 Free PMC article.
95.
Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer.
Grassberger C, Hong TS, Hato T, Yeap BY, Wo JY, Tracy M, Bortfeld T, Wolfgang JA, Eyler CE, Goyal L, Clark JW, Crane CH, Koay EJ, Cobbold M, DeLaney TF, Jain RK, Zhu AX, Duda DG.
Int J Radiat Oncol Biol Phys. 2018 Aug 1;101(5):1222-1225. doi: 10.1016/j.ijrobp.2018.04.026. Epub 2018 Apr 17.
PMID: 29859792 Free PMC article. Clinical Trial.
96.
Determining the Radiation Enhancement Effects of Gold Nanoparticles in Cells in a Combined Treatment with Cisplatin and Radiation at Therapeutic Megavoltage Energies.
Yang C, Bromma K, Sung W, Schuemann J, Chithrani D.
Cancers (Basel). 2018 May 22;10(5):150. doi: 10.3390/cancers10050150.
PMID: 29786642 Free PMC article.
97.
Robust Proton Treatment Planning: Physical and Biological Optimization.
Unkelbach J, Paganetti H.
Semin Radiat Oncol. 2018 Apr;28(2):88-96. doi: 10.1016/j.semradonc.2017.11.005.
PMID: 29735195 Free PMC article. Review.
98.
Can differences in linear energy transfer and thus relative biological effectiveness compromise the dosimetric advantage of intensity-modulated proton therapy as compared to passively scattered proton therapy?
Giantsoudi D, Adams J, MacDonald S, Paganetti H.
Acta Oncol. 2018 Sep;57(9):1259-1264. doi: 10.1080/0284186X.2018.1468090. Epub 2018 May 4.
PMID: 29726722 Clinical Trial.
99.
Monte Carlo simulation of chemistry following radiolysis with TOPAS-nBio.
Ramos-Méndez J, Perl J, Schuemann J, McNamara A, Paganetti H, Faddegon B.
Phys Med Biol. 2018 May 17;63(10):105014. doi: 10.1088/1361-6560/aac04c.
PMID: 29697057 Free PMC article.
100.
National Cancer Institute Workshop on Proton Therapy for Children: Considerations Regarding Brainstem Injury.
Haas-Kogan D, Indelicato D, Paganetti H, Esiashvili N, Mahajan A, Yock T, Flampouri S, MacDonald S, Fouladi M, Stephen K, Kalapurakal J, Terezakis S, Kooy H, Grosshans D, Makrigiorgos M, Mishra K, Poussaint TY, Cohen K, Fitzgerald T, Gondi V, Liu A, Michalski J, Mirkovic D, Mohan R, Perkins S, Wong K, Vikram B, Buchsbaum J, Kun L.
Int J Radiat Oncol Biol Phys. 2018 May 1;101(1):152-168. doi: 10.1016/j.ijrobp.2018.01.013.
PMID: 29619963 Free PMC article. Review.
101.
Brainstem Injury in Pediatric Patients With Posterior Fossa Tumors Treated With Proton Beam Therapy and Associated Dosimetric Factors.
Gentile MS, Yeap BY, Paganetti H, Goebel CP, Gaudet DE, Gallotto SL, Weyman EA, Morgan ML, MacDonald SM, Giantsoudi D, Adams J, Tarbell NJ, Kooy H, Yock TI.
Int J Radiat Oncol Biol Phys. 2018 Mar 1;100(3):719-729. doi: 10.1016/j.ijrobp.2017.11.026. Epub 2017 Nov 23.
PMID: 29413284
102.
Density overwrites of internal tumor volumes in intensity modulated proton therapy plans for mobile lung tumors.
Botas P, Grassberger C, Sharp G, Paganetti H.
Phys Med Biol. 2018 Jan 30;63(3):035023. doi: 10.1088/1361-6560/aaa035.
PMID: 29219119 Free PMC article.