Publications by our Team between 2018 and 2023

A review on lymphocyte radiosensitivity and its impact on radiotherapy.
Paganetti H.
Front Oncol. 2023 Aug 3;13:1201500. doi: 10.3389/fonc.2023.1201500. eCollection 2023.
PMID: 37601664 Free PMC article. Review.
The complexity of DNA damage by radiation follows a Gamma distribution: insights from the Microdosimetric Gamma Model.
Bertolet A, Chamseddine I, Paganetti H, Schuemann J.
Front Oncol. 2023 Jun 16;13:1196502. doi: 10.3389/fonc.2023.1196502. eCollection 2023.
PMID: 37397382 Free PMC article.
Increased flexibility and efficiency of a double-scattering FLASH proton beamline configuration forin vivoSOBP radiotherapy treatments.
Hachadorian R, Cascio E, Schuemann J.
Phys Med Biol. 2023 Jul 24;68(15). doi: 10.1088/1361-6560/ace23c.
PMID: 37369231
A systematic analysis of the particle irradiation data ensemble in the key of the microdosimetric kinetic model: Should clonogenic data be used for clinical relative biological effectiveness?
Suárez-García D, Cortés-Giraldo MA, Bertolet A.
Radiother Oncol. 2023 Aug;185:109730. doi: 10.1016/j.radonc.2023.109730. Epub 2023 Jun 9.
PMID: 37301260
An integrated Monte Carlo track-structure simulation framework for modeling inter and intra-track effects on homogenous chemistry.
D-Kondo JN, Garcia-Garcia OR, LaVerne JA, Faddegon B, Schuemann J, Shin WG, Ramos-Méndez J.
Phys Med Biol. 2023 Jun 9;68(12):10.1088/1361-6560/acd6d0. doi: 10.1088/1361-6560/acd6d0.
PMID: 37201533
Absence of Tissue-Sparing Effects in Partial Proton FLASH Irradiation in Murine Intestine.
Zhang Q, Gerweck LE, Cascio E, Gu L, Yang Q, Dong X, Huang P, Bertolet A, Nesteruk KP, Sung W, McNamara AL, Schuemann J.
Cancers (Basel). 2023 Apr 13;15(8):2269. doi: 10.3390/cancers15082269.
PMID: 37190197 Free PMC article.
Evaluating the effect of setup uncertainty reduction and adaptation to geometric changes on normal tissue complication probability using online adaptive head and neck intensity modulated proton therapy.
Lalonde A, Bobić M, Sharp GC, Chamseddine I, Winey B, Paganetti H.
Phys Med Biol. 2023 May 30;68(11):10.1088/1361-6560/acd433. doi: 10.1088/1361-6560/acd433.
PMID: 37164020
Framework for Quality Assurance of Ultrahigh Dose Rate Clinical Trials Investigating FLASH Effects and Current Technology Gaps.
Zou W, Zhang R, Schüler E, Taylor PA, Mascia AE, Diffenderfer ES, Zhao T, Ayan AS, Sharma M, Yu SJ, Lu W, Bosch WR, Tsien C, Surucu M, Pollard-Larkin JM, Schuemann J, Moros EG, Bazalova-Carter M, Gladstone DJ, Li H, Simone CB 2nd, Petersson K, Kry SF, Maity A, Loo BW Jr, Dong L, Maxim PG, Xiao Y, Buchsbaum JC.
Int J Radiat Oncol Biol Phys. 2023 Aug 1;116(5):1202-1217. doi: 10.1016/j.ijrobp.2023.04.018. Epub 2023 Apr 28.
PMID: 37121362 Review.
Large anatomical changes in head-and-neck cancers – A dosimetric comparison of online and offline adaptive proton therapy.
Bobić M, Lalonde A, Nesteruk KP, Lee H, Nenoff L, Gorissen BL, Bertolet A, Busse PM, Chan AW, Winey BA, Sharp GC, Verburg JM, Lomax AJ, Paganetti H.
Clin Transl Radiat Oncol. 2023 Mar 31;40:100625. doi: 10.1016/j.ctro.2023.100625. eCollection 2023 May.
PMID: 37090849 Free PMC article.
Intra-brain vascular models within the ICRP mesh-type adult reference phantoms for applications to internal dosimetry.
Correa-Alfonso CM, Withrow JD, Domal SJ, President BN, Dawson RJ, McCullum L, Beekman C, Grassberger C, Paganetti H, Bolch WE.
Phys Med Biol. 2023 May 2;68(10). doi: 10.1088/1361-6560/acc926.
PMID: 36996844
Modeling the impact of tissue oxygen profiles and oxygen depletion parameter uncertainties on biological response and therapeutic benefit of FLASH.
Zhu H, Schuemann J, Zhang Q, Gerweck LE.
Med Phys. 2023 Mar 20. doi: 10.1002/mp.16366. Online ahead of print.
PMID: 36939370
Neural network based ensemble model to predict radiation induced lymphopenia after concurrent chemo-radiotherapy for non-small cell lung cancer from two institutions.
Kim Y, Chamseddine I, Cho Y, Kim JS, Mohan R, Shusharina N, Paganetti H, Lin S, Yoon HI, Cho S, Grassberger C.
Neoplasia. 2023 May;39:100889. doi: 10.1016/j.neo.2023.100889. Epub 2023 Mar 15.
PMID: 36931040 Free PMC article.
TOPAS-imaging: extensions to the TOPAS simulation toolkit for medical imaging systems.
Lee H, Cheon BW, Feld JW, Grogg K, Perl J, Ramos-Méndez JA, Faddegon B, Min CH, Paganetti H, Schuemann J.
Phys Med Biol. 2023 Apr 3;68(8):10.1088/1361-6560/acc565. doi: 10.1088/1361-6560/acc565.
PMID: 36930985
Predictive Model of Liver Toxicity to Aid the Personalized Selection of Proton Versus Photon Therapy in Hepatocellular Carcinoma.
Chamseddine I, Kim Y, De B, Naqa IE, Duda DG, Wolfgang JA, Pursley J, Wo JY, Hong TS, Paganetti H, Koay EJ, Grassberger C.
Int J Radiat Oncol Biol Phys. 2023 Aug 1;116(5):1234-1243. doi: 10.1016/j.ijrobp.2023.01.055. Epub 2023 Feb 4.
PMID: 36739920
Predicting Severity of Radiation Induced Lymphopenia in Individual Proton Therapy Patients for Varying Dose Rate and Fractionation Using Dynamic 4-Dimensional Blood Flow Simulations.
McCullum L, Shin J, Xing S, Beekman C, Schuemann J, Hong T, Duda D, Mohan R, Lin SH, Correa-Alfonso CM, Domal S, Withrow J, Bolch W, Paganetti H, Grassberger C.
Int J Radiat Oncol Biol Phys. 2023 Aug 1;116(5):1226-1233. doi: 10.1016/j.ijrobp.2023.01.054. Epub 2023 Feb 4.
PMID: 36739919
Proton FLASH effects on mouse skin at different oxygen tensions.
Zhang Q, Gerweck LE, Cascio E, Yang Q, Huang P, Niemierko A, Bertolet A, Nesteruk KP, McNamara A, Schuemann J.
Phys Med Biol. 2023 Feb 27;68(5). doi: 10.1088/1361-6560/acb888.
PMID: 36731139
Prediction of DNA rejoining kinetics and cell survival after proton irradiation for V79 cells using Geant4-DNA.
Sakata D, Hirayama R, Shin WG, Belli M, Tabocchini MA, Stewart RD, Belov O, Bernal MA, Bordage MC, Brown JMC, Dordevic M, Emfietzoglou D, Francis Z, Guatelli S, Inaniwa T, Ivanchenko V, Karamitros M, Kyriakou I, Lampe N, Li Z, Meylan S, Michelet C, Nieminen P, Perrot Y, Petrovic I, Ramos-Mendez J, Ristic-Fira A, Santin G, Schuemann J, Tran HN, Villagrasa C, Incerti S.
Phys Med. 2023 Jan;105:102508. doi: 10.1016/j.ejmp.2022.11.012. Epub 2022 Dec 20.
PMID: 36549067
Low-Dose Computed Tomography Scanning Protocols for Online Adaptive Proton Therapy of Head-and-Neck Cancers.
Nesteruk KP, Bobić M, Sharp GC, Lalonde A, Winey BA, Nenoff L, Lomax AJ, Paganetti H.
Cancers (Basel). 2022 Oct 21;14(20):5155. doi: 10.3390/cancers14205155.
PMID: 36291939 Free PMC article.
Nano-scale simulation of neuronal damage by galactic cosmic rays.
Peter JS, Schuemann J, Held KD, McNamara AL.
Phys Med Biol. 2022 Nov 25;67(23):10.1088/1361-6560/ac95f4. doi: 10.1088/1361-6560/ac95f4.
PMID: 36172820
Development of Ultra-High Dose-Rate (FLASH) Particle Therapy.
Kim MM, Darafsheh A, Schuemann J, Dokic I, Lundh O, Zhao T, Ramos-Méndez J, Dong L, Petersson K.
IEEE Trans Radiat Plasma Med Sci. 2022 Mar;6(3):252-262. doi: 10.1109/trpms.2021.3091406. Epub 2021 Jun 22.
PMID: 36092270 Free PMC article.
Severe Radiation-Induced Lymphopenia Attenuates the Benefit of Durvalumab After Concurrent Chemoradiotherapy for NSCLC.
Jing W, Xu T, Wu L, Lopez PB, Grassberger C, Ellsworth SG, Mohan R, Hobbs BP, Blumenschein GR, Tu J, Altan M, Lee P, Liao Z, Lin SH.
JTO Clin Res Rep. 2022 Aug 7;3(9):100391. doi: 10.1016/j.jtocrr.2022.100391. eCollection 2022 Sep.
PMID: 36089921 Free PMC article.
Integrating Structure Propagation Uncertainties in the Optimization of Online Adaptive Proton Therapy Plans.
Nenoff L, Buti G, Bobić M, Lalonde A, Nesteruk KP, Winey B, Sharp GC, Sudhyadhom A, Paganetti H.
Cancers (Basel). 2022 Aug 14;14(16):3926. doi: 10.3390/cancers14163926.
PMID: 36010919 Free PMC article.
A systematic review of clinical studies on variable proton Relative Biological Effectiveness (RBE).
Underwood TSA, McNamara AL, Appelt A, Haviland JS, Sørensen BS, Troost EGC.
Radiother Oncol. 2022 Oct;175:79-92. doi: 10.1016/j.radonc.2022.08.014. Epub 2022 Aug 18.
PMID: 35988776 Review.
Treatment planning considerations for the development of FLASH proton therapy.
Rothwell B, Lowe M, Traneus E, Krieger M, Schuemann J.
Radiother Oncol. 2022 Oct;175:222-230. doi: 10.1016/j.radonc.2022.08.003. Epub 2022 Aug 10.
PMID: 35963397 Free PMC article. Review.
Lymphocyte Depletion Rate as a Biomarker of Radiation Dose to Circulating Lymphocytes During Fractionated Partial-Body Radiation Therapy.
Ellsworth SG, Yalamanchali A, Lautenschlaeger T, Grossman SA, Grassberger C, Lin SH, Mohan R.
Adv Radiat Oncol. 2022 Apr 8;7(5):100959. doi: 10.1016/j.adro.2022.100959. eCollection 2022 Sep-Oct.
PMID: 35928987 Free PMC article.
MOQUI: an open-source GPU-based Monte Carlo code for proton dose calculation with efficient data structure.
Lee H, Shin J, Verburg JM, Bobić M, Winey B, Schuemann J, Paganetti H.
Phys Med Biol. 2022 Aug 30;67(17):10.1088/1361-6560/ac8716. doi: 10.1088/1361-6560/ac8716.
PMID: 35926482
Weekly Nowcasting of New COVID-19 Cases Using Past Viral Load Measurements.
Khalil A, Al Handawi K, Mohsen Z, Abdel Nour A, Feghali R, Chamseddine I, Kokkolaras M.
Viruses. 2022 Jun 28;14(7):1414. doi: 10.3390/v14071414.
PMID: 35891394 Free PMC article.
A computational approach to quantifying miscounting of radiation-induced double-strand break immunofluorescent foci.
Ingram SP, Warmenhoven JW, Henthorn NT, Chadiwck AL, Santina EE, McMahon SJ, Schuemann J, Kirkby NF, Mackay RI, Kirkby KJ, Merchant MJ.
Commun Biol. 2022 Jul 14;5(1):700. doi: 10.1038/s42003-022-03585-5.
PMID: 35835982 Free PMC article.
National Effort to Re-Establish Heavy Ion Cancer Therapy in the United States.
Pompos A, Foote RL, Koong AC, Le QT, Mohan R, Paganetti H, Choy H.
Front Oncol. 2022 Jun 14;12:880712. doi: 10.3389/fonc.2022.880712. eCollection 2022.
PMID: 35774126 Free PMC article. Review.
Impact of DNA Geometry and Scoring on Monte Carlo Track-Structure Simulations of Initial Radiation-Induced Damage.
Bertolet A, Ramos-Méndez J, McNamara A, Yoo D, Ingram S, Henthorn N, Warmenhoven JW, Faddegon B, Merchant M, McMahon SJ, Paganetti H, Schuemann J.
Radiat Res. 2022 Sep 1;198(3):207-220. doi: 10.1667/RADE-21-00179.1.
PMID: 35767729
TOPAS-nBio simulation of temperature-dependent indirect DNA strand break yields.
Ramos-Méndez J, García-García O, Domínguez-Kondo J, LaVerne JA, Schuemann J, Moreno-Barbosa E, Faddegon B.
Phys Med Biol. 2022 Jul 8;67(14):10.1088/1361-6560/ac79f9. doi: 10.1088/1361-6560/ac79f9.
PMID: 35714599 Free PMC article.
Consistency checks of results from a Monte Carlo code intercomparison for emitted electron spectra and energy deposition around a single gold nanoparticle irradiated by X-rays.
Rabus H, Li WB, Nettelbeck H, Schuemann J, Villagrasa C, Beuve M, Di Maria S, Heide B, Klapproth AP, Poignant F, Qiu R, Rudek B.
Radiat Meas. 2021 Sep;147:106637. doi: 10.1016/j.radmeas.2021.106637. Epub 2021 Jul 30.
PMID: 35669292 Free PMC article.
Modified Geometry of 106Ru Asymmetric Eye Plaques to Improve Dosimetric Calculations in Ophthalmic Brachytherapy.
Miras H, Terrón JA, Bertolet A, Leal A.
J Pers Med. 2022 Apr 29;12(5):723. doi: 10.3390/jpm12050723.
PMID: 35629144 Free PMC article.
A mesh-based model of liver vasculature: implications for improved radiation dosimetry to liver parenchyma for radiopharmaceuticals.
Correa-Alfonso CM, Withrow JD, Domal SJ, Xing S, Shin J, Grassberger C, Paganetti H, Bolch WE.
EJNMMI Phys. 2022 Apr 13;9(1):28. doi: 10.1186/s40658-022-00456-0.
PMID: 35416550 Free PMC article.
Predictive Modeling of Survival and Toxicity in Patients With Hepatocellular Carcinoma After Radiotherapy.
Chamseddine I, Kim Y, De B, El Naqa I, Duda DG, Wolfgang J, Pursley J, Paganetti H, Wo J, Hong T, Koay EJ, Grassberger C.
JCO Clin Cancer Inform. 2022 Feb;6:e2100169. doi: 10.1200/CCI.21.00169.
PMID: 35192402 Free PMC article.
Implementation of apertures in a proton pencil-beam dose algorithm.
Depauw N, Kooy HM, Daartz J, Bussière M, Batin E, Madden T, Williams M, Schueman J, Clasie BM.
Biomed Phys Eng Express. 2022 Feb 25;8(2). doi: 10.1088/2057-1976/ac550b.
PMID: 35158343
Dosimetric Modeling of Lymphopenia in Patients With Metastatic Cancer Receiving Palliative Radiation and PD-1 Immune Checkpoint Inhibitors.
Qian JM, Akama-Garren E, Shin J, Gunasti L, Bang A, Pike LRG, Grassberger C, Schoenfeld JD.
Adv Radiat Oncol. 2021 Dec 24;7(2):100880. doi: 10.1016/j.adro.2021.100880. eCollection 2022 Mar-Apr.
PMID: 35097241 Free PMC article.
Spatiotemporal optimisation of prostate intensity modulated proton therapy (IMPT) treatments.
Manganaro L, Attili A, Bortfeld T, Paganetti H.
Phys Med Biol. 2022 Feb 10;67(4). doi: 10.1088/1361-6560/ac4fa2.
PMID: 35086079
A dynamic blood flow model to compute absorbed dose to circulating blood and lymphocytes in liver external beam radiotherapy.
Xing S, Shin J, Pursley J, Correa-Alfonso CM, Depauw N, Domal S, Withrow J, Bolch W, Grassberger C, Paganetti H.
Phys Med Biol. 2022 Feb 15;67(4):10.1088/1361-6560/ac4da4. doi: 10.1088/1361-6560/ac4da4.
PMID: 35061601 Free PMC article.
Lymphocyte dynamics during and after chemo-radiation correlate to dose and outcome in stage III NSCLC patients undergoing maintenance immunotherapy.
Cho Y, Kim Y, Chamseddine I, Lee WH, Kim HR, Lee IJ, Hong MH, Cho BC, Lee CG, Cho S, Kim JS, Yoon HI, Grassberger C.
Radiother Oncol. 2022 Mar;168:1-7. doi: 10.1016/j.radonc.2022.01.007. Epub 2022 Jan 13.
PMID: 35033601 Free PMC article.
Pre- and post-treatment image-based dosimetry in90Y-microsphere radioembolization using the TOPAS Monte Carlo toolkit.
Bertolet A, Wehrenberg-Klee E, Bobić M, Grassberger C, Perl J, Paganetti H, Schuemann J.
Phys Med Biol. 2021 Dec 29;66(24):10.1088/1361-6560/ac43fd. doi: 10.1088/1361-6560/ac43fd.
PMID: 34915451 Free PMC article.
CT-on-Rails Versus In-Room CBCT for Online Daily Adaptive Proton Therapy of Head-and-Neck Cancers.
Nesteruk KP, Bobić M, Lalonde A, Winey BA, Lomax AJ, Paganetti H.
Cancers (Basel). 2021 Nov 28;13(23):5991. doi: 10.3390/cancers13235991.
PMID: 34885100 Free PMC article.
DNA damage modeled with Geant4-DNA: effects of plasmid DNA conformation and experimental conditions.
D-Kondo N, Moreno-Barbosa E, Štěphán V, Stefanová K, Perrot Y, Villagrasa C, Incerti S, De Celis Alonso B, Schuemann J, Faddegon B, Ramos-Méndez J.
Phys Med Biol. 2021 Dec 15;66(24):10.1088/1361-6560/ac3a22. doi: 10.1088/1361-6560/ac3a22.
PMID: 34787099 Free PMC article.
Mathematical Modeling to Simulate the Effect of Adding Radiation Therapy to Immunotherapy and Application to Hepatocellular Carcinoma.
Sung W, Hong TS, Poznansky MC, Paganetti H, Grassberger C.
Int J Radiat Oncol Biol Phys. 2022 Mar 15;112(4):1055-1062. doi: 10.1016/j.ijrobp.2021.11.008. Epub 2021 Nov 11.
PMID: 34774999 Free PMC article.
Application of High-Z Gold Nanoparticles in Targeted Cancer Radiotherapy-Pharmacokinetic Modeling, Monte Carlo Simulation and Radiobiological Effect Modeling.
Li WB, Stangl S, Klapproth A, Shevtsov M, Hernandez A, Kimm MA, Schuemann J, Qiu R, Michalke B, Bernal MA, Li J, Hürkamp K, Zhang Y, Multhoff G.
Cancers (Basel). 2021 Oct 26;13(21):5370. doi: 10.3390/cancers13215370.
PMID: 34771534 Free PMC article.
Radiation-Induced Lymphopenia Risks of Photon Versus Proton Therapy for Esophageal Cancer Patients.
Ebrahimi S, Lim G, Liu A, Lin SH, Ellsworth SG, Grassberger C, Mohan R, Cao W.
Int J Part Ther. 2021 Apr 7;8(2):17-27. doi: 10.14338/IJPT-20-00086. eCollection 2021 Fall.
PMID: 34722808 Free PMC article.
Adaptive proton therapy.
Paganetti H, Botas P, Sharp GC, Winey B.
Phys Med Biol. 2021 Nov 15;66(22):10.1088/1361-6560/ac344f. doi: 10.1088/1361-6560/ac344f.
PMID: 34710858 Free PMC article. Review.
Single-Cell Profiling Reveals Metabolic Reprogramming as a Resistance Mechanism in BRAF-Mutated Multiple Myeloma.
Waldschmidt JM, Kloeber JA, Anand P, Frede J, Kokkalis A, Dimitrova V, Potdar S, Nair MS, Vijaykumar T, Im NG, Guillaumet-Adkins A, Chopra N, Stuart H, Budano L, Sotudeh N, Guo G, Grassberger C, Yee AJ, Laubach JP, Richardson PG, Anderson KC, Raje NS, Knoechel B, Lohr JG.
Clin Cancer Res. 2021 Dec 1;27(23):6432-6444. doi: 10.1158/1078-0432.CCR-21-2040. Epub 2021 Sep 13.
PMID: 34518309 Free PMC article.
Correlation of LET With MRI Changes in Brain and Potential Implications for Normal Tissue Complication Probability for Patients With Meningioma Treated With Pencil Beam Scanning Proton Therapy.
Bertolet A, Abolfath R, Carlson DJ, Lustig RA, Hill-Kayser C, Alonso-Basanta M, Carabe A.
Int J Radiat Oncol Biol Phys. 2022 Jan 1;112(1):237-246. doi: 10.1016/j.ijrobp.2021.08.027. Epub 2021 Aug 21.
PMID: 34425196
TOPAS-nBio validation for simulating water radiolysis and DNA damage under low-LET irradiation.
Ramos-Méndez J, LaVerne JA, Domínguez-Kondo N, Milligan J, Štěpán V, Stefanová K, Perrot Y, Villagrasa C, Shin WG, Incerti S, McNamara A, Paganetti H, Perl J, Schuemann J, Faddegon B.
Phys Med Biol. 2021 Sep 3;66(17):10.1088/1361-6560/ac1f39. doi: 10.1088/1361-6560/ac1f39.
PMID: 34412044 Free PMC article.
Mechanisms and Review of Clinical Evidence of Variations in Relative Biological Effectiveness in Proton Therapy.
Paganetti H.
Int J Radiat Oncol Biol Phys. 2022 Jan 1;112(1):222-236. doi: 10.1016/j.ijrobp.2021.08.015. Epub 2021 Aug 15.
PMID: 34407443 Free PMC article. Review.
Monte Carlo methods for device simulations in radiation therapy.
Park H, Paganetti H, Schuemann J, Jia X, Min CH.
Phys Med Biol. 2021 Sep 14;66(18):10.1088/1361-6560/ac1d1f. doi: 10.1088/1361-6560/ac1d1f.
PMID: 34384063 Free PMC article. Review.
HEDOS-a computational tool to assess radiation dose to circulating blood cells during external beam radiotherapy based on whole-body blood flow simulations.
Shin J, Xing S, McCullum L, Hammi A, Pursley J, Correa CA, Withrow J, Domal S, Bolch W, Paganetti H, Grassberger C.
Phys Med Biol. 2021 Aug 3;66(16):10.1088/1361-6560/ac16ea. doi: 10.1088/1361-6560/ac16ea.
PMID: 34293735 Free PMC article.
The Biological Basis for Enhanced Effects of Proton Radiation Therapy Relative to Photon Radiation Therapy for Head and Neck Squamous Cell Carcinoma.
Wang L, Fossati P, Paganetti H, Ma L, Gillison M, Myers JN, Hug E, Frank SJ.
Int J Part Ther. 2021 Jun 25;8(1):3-13. doi: 10.14338/IJPT-20-00070.1. eCollection 2021 Summer.
PMID: 34285931 Free PMC article.
Proton vs. photon radiotherapy for MR-guided dose escalation of intraprostatic lesions.
Moteabbed M, Harisinghani M, Paganetti H, Trofimov A, Lu HM, Efstathiou JA.
Acta Oncol. 2021 Oct;60(10):1283-1290. doi: 10.1080/0284186X.2021.1947523. Epub 2021 Jul 20.
PMID: 34282708
The relation between microdosimetry and induction of direct damage to DNA by alpha particles.
Bertolet A, Ramos-Méndez J, Paganetti H, Schuemann J.
Phys Med Biol. 2021 Jul 30;66(15):10.1088/1361-6560/ac15a5. doi: 10.1088/1361-6560/ac15a5.
PMID: 34280910 Free PMC article.
Modelling treatment-response rates.
Grassberger C, Ngwa W.
Nat Biomed Eng. 2021 Apr;5(4):295-296. doi: 10.1038/s41551-021-00717-w.
PMID: 33864036 Free PMC article.
Intercomparison of Monte Carlo calculated dose enhancement ratios for gold nanoparticles irradiated by X-rays: Assessing the uncertainty and correct methodology for extended beams.
Rabus H, Li WB, Villagrasa C, Schuemann J, Hepperle PA, de la Fuente Rosales L, Beuve M, Di Maria S, Klapproth AP, Li CY, Poignant F, Rudek B, Nettelbeck H.
Phys Med. 2021 Apr;84:241-253. doi: 10.1016/j.ejmp.2021.03.005. Epub 2021 Mar 23.
PMID: 33766478 Free PMC article.
Anatomic changes in head and neck intensity-modulated proton therapy: Comparison between robust optimization and online adaptation.
Lalonde A, Bobić M, Winey B, Verburg J, Sharp GC, Paganetti H.
Radiother Oncol. 2021 Jun;159:39-47. doi: 10.1016/j.radonc.2021.03.008. Epub 2021 Mar 17.
PMID: 33741469 Free PMC article.
Radiation-Associated Lymphopenia and Outcomes of Patients with Unresectable Hepatocellular Carcinoma Treated with Radiotherapy.
De B, Ng SP, Liu AY, Avila S, Tao R, Holliday EB, Brownlee Z, Kaseb A, Lee S, Raghav K, Vauthey JN, Minsky BD, Herman JM, Das P, Smith GL, Taniguchi CM, Krishnan S, Crane CH, Grassberger C, Hong TS, Lin SH, Koong AC, Mohan R, Koay EJ.
J Hepatocell Carcinoma. 2021 Mar 3;8:57-69. doi: 10.2147/JHC.S282062. eCollection 2021.
PMID: 33688489 Free PMC article.
Physics of Particle Beam and Hypofractionated Beam Delivery in NSCLC.
Paganetti H, Grassberger C, Sharp GC.
Semin Radiat Oncol. 2021 Apr;31(2):162-169. doi: 10.1016/j.semradonc.2020.11.004.
PMID: 33610274 Free PMC article. Review.
Brain-Specific Relative Biological Effectiveness of Protons Based on Long-term Outcome of Patients With Nasopharyngeal Carcinoma.
Zhang YY, Huo WL, Goldberg SI, Slater JM, Adams JA, Deng XW, Sun Y, Ma J, Fullerton BC, Paganetti H, Loeffler JS, Lu HM, Chan AW.
Int J Radiat Oncol Biol Phys. 2021 Jul 15;110(4):984-992. doi: 10.1016/j.ijrobp.2021.02.018. Epub 2021 Feb 16.
PMID: 33600889 Clinical Trial.
Targeting the DNA replication stress phenotype of KRAS mutant cancer cells.
Al Zubaidi T, Gehrisch OHF, Genois MM, Liu Q, Lu S, Kung J, Xie Y, Schuemann J, Lu HM, Hata AN, Zou L, Borgmann K, Willers H.
Sci Rep. 2021 Feb 11;11(1):3656. doi: 10.1038/s41598-021-83142-y.
PMID: 33574444 Free PMC article.
Circulating Lymphocyte Counts Early During Radiation Therapy Are Associated With Recurrence in Pediatric Medulloblastoma.
Grassberger C, Shinnick D, Yeap BY, Tracy M, G Ellsworth S, Hess CB, Weyman EA, Gallotto SL, Lawell MP, Bajaj B, Ebb DH, Ioakeim-Ioannidou M, Loeffler JS, MacDonald SM, Tarbell NJ, Yock TI.
Int J Radiat Oncol Biol Phys. 2021 Jul 15;110(4):1044-1052. doi: 10.1016/j.ijrobp.2021.01.035. Epub 2021 Feb 5.
PMID: 33556478 Free PMC article.
The impact of variable relative biological effectiveness in proton therapy for left-sided breast cancer when estimating normal tissue complications in the heart and lung.
Marteinsdottir M, Wang CC, McNamara A, Depauw N, Shin J, Paganetti H.
Phys Med Biol. 2021 Jan 30;66(3):035023. doi: 10.1088/1361-6560/abd230.
PMID: 33522498
Comparison of weekly and daily online adaptation for head and neck intensity-modulated proton therapy.
Bobić M, Lalonde A, Sharp GC, Grassberger C, Verburg JM, Winey BA, Lomax AJ, Paganetti H.
Phys Med Biol. 2021 Feb 25;66(5):10.1088/1361-6560/abe050. doi: 10.1088/1361-6560/abe050.
PMID: 33503592 Free PMC article.
A Multi-institutional Comparative Analysis of Proton and Photon Therapy-Induced Hematologic Toxicity in Patients With Medulloblastoma.
Liu KX, Ioakeim-Ioannidou M, Susko MS, Rao AD, Yeap BY, Snijders AM, Ladra MM, Vogel J, Zaslowe-Dude C, Marcus KJ, Yock TI, Grassberger C, Braunstein SE, Haas-Kogan DA, Terezakis SA, MacDonald SM.
Int J Radiat Oncol Biol Phys. 2021 Mar 1;109(3):726-735. doi: 10.1016/j.ijrobp.2020.09.049. Epub 2020 Nov 23.
PMID: 33243479
Roadmap: proton therapy physics and biology.
Paganetti H, Beltran C, Both S, Dong L, Flanz J, Furutani K, Grassberger C, Grosshans DR, Knopf AC, Langendijk JA, Nystrom H, Parodi K, Raaymakers BW, Richter C, Sawakuchi GO, Schippers M, Shaitelman SF, Teo BKK, Unkelbach J, Wohlfahrt P, Lomax T.
Phys Med Biol. 2021 Feb 26;66(5):10.1088/1361-6560/abcd16. doi: 10.1088/1361-6560/abcd16.
PMID: 33227715 Free PMC article. Review.
“Cancer risk after breast proton therapy considering physiological and radiobiological uncertainties” by Raptis et al. (Physica Medica 76 (2020) 1-6).
Paganetti H.
Phys Med. 2020 Dec;80:274-276. doi: 10.1016/j.ejmp.2020.11.008. Epub 2020 Nov 20.
PMID: 33227626
FLASH Investigations Using Protons: Design of Delivery System, Preclinical Setup and Confirmation of FLASH Effect with Protons in Animal Systems.
Zhang Q, Cascio E, Li C, Yang Q, Gerweck LE, Huang P, Gottschalk B, Flanz J, Schuemann J.
Radiat Res. 2020 Dec 1;194(6):656-664. doi: 10.1667/RADE-20-00068.1.
PMID: 32991708
Brain Necrosis in Adult Patients After Proton Therapy: Is There Evidence for Dependency on Linear Energy Transfer?
Niemierko A, Schuemann J, Niyazi M, Giantsoudi D, Maquilan G, Shih HA, Paganetti H.
Int J Radiat Oncol Biol Phys. 2021 Jan 1;109(1):109-119. doi: 10.1016/j.ijrobp.2020.08.058. Epub 2020 Sep 7.
PMID: 32911019 Free PMC article.
Challenges in the quantification approach to a radiation relevant adverse outcome pathway for lung cancer.
Stainforth R, Schuemann J, McNamara AL, Wilkins RC, Chauhan V.
Int J Radiat Biol. 2021;97(1):85-101. doi: 10.1080/09553002.2020.1820096. Epub 2020 Sep 30.
PMID: 32909875 Free PMC article.
Modeling Resistance and Recurrence Patterns of Combined Targeted-Chemoradiotherapy Predicts Benefit of Shorter Induction Period.
McClatchy DM, Willers H, Hata AN, Piotrowska Z, Sequist LV, Paganetti H, Grassberger C.
Cancer Res. 2020 Nov 15;80(22):5121-5133. doi: 10.1158/0008-5472.CAN-19-3883. Epub 2020 Sep 9.
PMID: 32907839 Free PMC article.
LET-Dependent Intertrack Yields in Proton Irradiation at Ultra-High Dose Rates Relevant for FLASH Therapy.
Ramos-Méndez J, Domínguez-Kondo N, Schuemann J, McNamara A, Moreno-Barbosa E, Faddegon B.
Radiat Res. 2020 Oct 2;194(4):351-362. doi: 10.1667/RADE-20-00084.1.
PMID: 32857855 Free PMC article.
Proton therapy reduces the likelihood of high-grade radiation-induced lymphopenia in glioblastoma patients: phase II randomized study of protons vs photons.
Mohan R, Liu AY, Brown PD, Mahajan A, Dinh J, Chung C, McAvoy S, McAleer MF, Lin SH, Li J, Ghia AJ, Zhu C, Sulman EP, de Groot JF, Heimberger AB, McGovern SL, Grassberger C, Shih H, Ellsworth S, Grosshans DR.
Neuro Oncol. 2021 Feb 25;23(2):284-294. doi: 10.1093/neuonc/noaa182.
PMID: 32750703 Free PMC article. Clinical Trial.
Prolongation of radiotherapy duration is associated with inferior overall survival in patients with pediatric medulloblastoma and central nervous system primitive neuroectodermal tumors.
Baliga S, Bajaj BVM, Kabarriti R, Grassberger C, Patteson B, Yeap B, Fox JL, Garg MK, Yock TI.
Pediatr Blood Cancer. 2020 Oct;67(10):e28558. doi: 10.1002/pbc.28558. Epub 2020 Jul 25.
PMID: 32710698
A tumor-immune interaction model for hepatocellular carcinoma based on measured lymphocyte counts in patients undergoing radiotherapy.
Sung W, Grassberger C, McNamara AL, Basler L, Ehrbar S, Tanadini-Lang S, Hong TS, Paganetti H.
Radiother Oncol. 2020 Oct;151:73-81. doi: 10.1016/j.radonc.2020.07.025. Epub 2020 Jul 15.
PMID: 32679308 Free PMC article.
Evaluation of CBCT scatter correction using deep convolutional neural networks for head and neck adaptive proton therapy.
Lalonde A, Winey B, Verburg J, Paganetti H, Sharp GC.
Phys Med Biol. 2020 Dec 4;65(24):10.1088/1361-6560/ab9fcb. doi: 10.1088/1361-6560/ab9fcb.
PMID: 32580174 Free PMC article.
The risk for developing a secondary cancer after breast radiation therapy: Comparison of photon and proton techniques.
Paganetti H, Depauw N, Johnson A, Forman RB, Lau J, Jimenez R.
Radiother Oncol. 2020 Aug;149:212-218. doi: 10.1016/j.radonc.2020.05.035. Epub 2020 May 25.
PMID: 32464163
Assessing second cancer risk after primary cancer treatment with photon or proton radiotherapy.
DeLaney TF, Yock TI, Paganetti H.
Cancer. 2020 Aug 1;126(15):3397-3399. doi: 10.1002/cncr.32936. Epub 2020 May 19.
PMID: 32426850 No abstract available.
Optimizing Radiation Therapy to Boost Systemic Immune Responses in Breast Cancer: A Critical Review for Breast Radiation Oncologists.
Ho AY, Wright JL, Blitzblau RC, Mutter RW, Duda DG, Norton L, Bardia A, Spring L, Isakoff SJ, Chen JH, Grassberger C, Bellon JR, Beriwal S, Khan AJ, Speers C, Dunn SA, Thompson A, Santa-Maria CA, Krop IE, Mittendorf E, King TA, Gupta GP.
Int J Radiat Oncol Biol Phys. 2020 Sep 1;108(1):227-241. doi: 10.1016/j.ijrobp.2020.05.011. Epub 2020 May 14.
PMID: 32417409 Free PMC article. Review.
Cellular Response to Proton Irradiation: A Simulation Study with TOPAS-nBio.
Zhu H, McNamara AL, McMahon SJ, Ramos-Mendez J, Henthorn NT, Faddegon B, Held KD, Perl J, Li J, Paganetti H, Schuemann J.
Radiat Res. 2020 Jul 8;194(1):9-21. doi: 10.1667/RR15531.1.
PMID: 32401689 Free PMC article.
DICOM-RT Ion interface to utilize MC simulations in routine clinical workflow for proton pencil beam radiotherapy.
Shin J, Kooy HM, Paganetti H, Clasie B.
Phys Med. 2020 Jun;74:1-10. doi: 10.1016/j.ejmp.2020.04.018. Epub 2020 May 7.
PMID: 32388464 Free PMC article.
Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions.
Schuemann J, Bagley AF, Berbeco R, Bromma K, Butterworth KT, Byrne HL, Chithrani BD, Cho SH, Cook JR, Favaudon V, Gholami YH, Gargioni E, Hainfeld JF, Hespeels F, Heuskin AC, Ibeh UM, Kuncic Z, Kunjachan S, Lacombe S, Lucas S, Lux F, McMahon S, Nevozhay D, Ngwa W, Payne JD, Penninckx S, Porcel E, Prise KM, Rabus H, Ridwan SM, Rudek B, Sanche L, Singh B, Smilowitz HM, Sokolov KV, Sridhar S, Stanishevskiy Y, Sung W, Tillement O, Virani N, Yantasee W, Krishnan S.
Phys Med Biol. 2020 Oct 22;65(21):21RM02. doi: 10.1088/1361-6560/ab9159.
PMID: 32380492 Review.
Dosimetric Analysis and Normal-Tissue Complication Probability Modeling of Child-Pugh Score and Albumin-Bilirubin Grade Increase After Hepatic Irradiation.
Pursley J, El Naqa I, Sanford NN, Noe B, Wo JY, Eyler CE, Hwang M, Brock KK, Yeap BY, Wolfgang JA, Hong TS, Grassberger C.
Int J Radiat Oncol Biol Phys. 2020 Aug 1;107(5):986-995. doi: 10.1016/j.ijrobp.2020.04.027. Epub 2020 Apr 27.
PMID: 32353390 Free PMC article.
The TOPAS tool for particle simulation, a Monte Carlo simulation tool for physics, biology and clinical research.
Faddegon B, Ramos-Méndez J, Schuemann J, McNamara A, Shin J, Perl J, Paganetti H.
Phys Med. 2020 Apr;72:114-121. doi: 10.1016/j.ejmp.2020.03.019. Epub 2020 Apr 3.
PMID: 32247964 Free PMC article.
End-of-Range Radiobiological Effect on Rib Fractures in Patients Receiving Proton Therapy for Breast Cancer.
Wang CC, McNamara AL, Shin J, Schuemann J, Grassberger C, Taghian AG, Jimenez RB, MacDonald SM, Paganetti H.
Int J Radiat Oncol Biol Phys. 2020 Jul 1;107(3):449-454. doi: 10.1016/j.ijrobp.2020.03.012. Epub 2020 Mar 30.
PMID: 32240774 Free PMC article.
Perspectives on the model-based approach to proton therapy trials: A retrospective study of a lung cancer randomized trial.
McNamara AL, Hall DC, Shusharina N, Liu A, Wei X, Ajdari A, Mohan R, Liao Z, Paganetti H.
Radiother Oncol. 2020 Jun;147:8-14. doi: 10.1016/j.radonc.2020.02.022. Epub 2020 Mar 27.
PMID: 32224318 Free PMC article. Clinical Trial.
Modeling RBE-weighted dose variations in irregularly moving abdominal targets treated with carbon ion beams.
Meschini G, Kamp F, Hofmaier J, Reiner M, Sharp G, Paganetti H, Belka C, Wilkens JJ, Carlson DJ, Parodi K, Baroni G, Riboldi M.
Med Phys. 2020 Jul;47(7):2768-2778. doi: 10.1002/mp.14135. Epub 2020 Apr 18.
PMID: 32162332
4D blood flow model for dose calculation to circulating blood and lymphocytes.
Hammi A, Paganetti H, Grassberger C.
Phys Med Biol. 2020 Mar 2;65(5):055008. doi: 10.1088/1361-6560/ab6c41.
PMID: 32119649 Free PMC article.
A parameter sensitivity study for simulating DNA damage after proton irradiation using TOPAS-nBio.
Zhu H, McNamara AL, Ramos-Mendez J, McMahon SJ, Henthorn NT, Faddegon B, Held KD, Perl J, Li J, Paganetti H, Schuemann J.
Phys Med Biol. 2020 Apr 23;65(8):085015. doi: 10.1088/1361-6560/ab7a6b.
PMID: 32101803 Free PMC article.
Intercomparison of dose enhancement ratio and secondary electron spectra for gold nanoparticles irradiated by X-rays calculated using multiple Monte Carlo simulation codes.
Li WB, Belchior A, Beuve M, Chen YZ, Di Maria S, Friedland W, Gervais B, Heide B, Hocine N, Ipatov A, Klapproth AP, Li CY, Li JL, Multhoff G, Poignant F, Qiu R, Rabus H, Rudek B, Schuemann J, Stangl S, Testa E, Villagrasa C, Xie WZ, Zhang YB.
Phys Med. 2020 Jan;69:147-163. doi: 10.1016/j.ejmp.2019.12.011. Epub 2020 Jan 6.
PMID: 31918367 Free PMC article.
Modulation of nanoparticle uptake, intracellular distribution, and retention with docetaxel to enhance radiotherapy.
Bannister AH, Bromma K, Sung W, Monica M, Cicon L, Howard P, Chow RL, Schuemann J, Chithrani DB.
Br J Radiol. 2020 Feb 1;93(1106):20190742. doi: 10.1259/bjr.20190742. Epub 2019 Dec 12.
PMID: 31778316 Free PMC article.
Comparing 2 Monte Carlo Systems in Use for Proton Therapy Research.
Newpower M, Schuemann J, Mohan R, Paganetti H, Titt U.
Int J Part Ther. 2019 Summer;6(1):18-27. doi: 10.14338/IJPT-18-00043.1. Epub 2019 May 3.
PMID: 31773045 Free PMC article.
Modelling variable proton relative biological effectiveness for treatment planning.
McNamara A L, Willers H, Paganetti H.
Br J Radiol. 2020 Mar;93(1107):20190334. doi: 10.1259/bjr.20190334. Epub 2019 Nov 18.
PMID: 31738081 Free PMC article. Review.
Pragmatic randomised clinical trial of proton versus photon therapy for patients with non-metastatic breast cancer: the Radiotherapy Comparative Effectiveness (RadComp) Consortium trial protocol.
Bekelman JE, Lu H, Pugh S, Baker K, Berg CD, Berrington de González A, Braunstein LZ, Bosch W, Chauhan C, Ellenberg S, Fang LC, Freedman GM, Hahn EA, Haffty BG, Khan AJ, Jimenez RB, Kesslering C, Ky B, Lee C, Lu HM, Mishra MV, Mullins CD, Mutter RW, Nagda S, Pankuch M, Powell SN, Prior FW, Schupak K, Taghian AG, Wilkinson JB, MacDonald SM, Cahlon O; RadComp (Radiotherapy Comparative Effectiveness Consortium).
BMJ Open. 2019 Oct 15;9(10):e025556. doi: 10.1136/bmjopen-2018-025556.
PMID: 31619413 Free PMC article.
A dual-stream deep convolutional network for reducing metal streak artifacts in CT images.
Gjesteby L, Shan H, Yang Q, Xi Y, Jin Y, Giantsoudi D, Paganetti H, De Man B, Wang G.
Phys Med Biol. 2019 Nov 26;64(23):235003. doi: 10.1088/1361-6560/ab4e3e.
PMID: 31618724
Three discipline collaborative radiation therapy (3DCRT) special debate: The single most important factor in determining the future of SBRT is immune response.
Grassberger C, Huber K, Jacob NK, Green MD, Mahler P, Prisciandaro J, Dominello M, Joiner MC, Burmeister J.
J Appl Clin Med Phys. 2019 Oct;20(10):6-12. doi: 10.1002/acm2.12728. Epub 2019 Oct 1.
PMID: 31573143 Free PMC article. No abstract available.
Volumetric and actuarial analysis of brain necrosis in proton therapy using a novel mixture cure model.
Niyazi M, Niemierko A, Paganetti H, Söhn M, Schapira E, Goldberg S, Adams J, Kim V, Oh KS, Hwang WL, Lu HM, Belka C, Busse PM, Loeffler JS, Shih HA.
Radiother Oncol. 2020 Jan;142:154-161. doi: 10.1016/j.radonc.2019.09.008. Epub 2019 Sep 25.
PMID: 31563411
A review on cathode materials for advanced lithium ion batteries: microstructure designs and performance regulations.
Chen Z, Zhang W, Yang Z.
Nanotechnology. 2020 Jan 3;31(1):012001. doi: 10.1088/1361-6528/ab4447. Epub 2019 Sep 13.
PMID: 31519017
Impact of uncertainties in range and RBE on small field proton therapy.
Marteinsdottir M, Schuemann J, Paganetti H.
Phys Med Biol. 2019 Oct 10;64(20):205005. doi: 10.1088/1361-6560/ab448f.
PMID: 31519016
Monte Carlo Processing on a Chip (MCoaC)-preliminary experiments toward the realization of optimal-hardware for TOPAS/Geant4 to drive discovery.
Abhyankar YS, Dev S, Sarun OS, Saxena A, Joshi R, Darbari H, Sajish C, Sonavane UB, Gavane V, Deshpande A, Dixit T, Harsh R, Badwe R, Rath GK, Laskar S, Faddegon B, Perl J, Paganetti H, Schuemann J, Srivastava A, Obcemea C, Nath AK, Sharma A, Buchsbaum J.
Phys Med. 2019 Aug;64:166-173. doi: 10.1016/j.ejmp.2019.06.016. Epub 2019 Jul 16.
PMID: 31515016 Free PMC article.
Radio-enhancement by gold nanoparticles and their impact on water radiolysis for x-ray, proton and carbon-ion beams.
Rudek B, McNamara A, Ramos-Méndez J, Byrne H, Kuncic Z, Schuemann J.
Phys Med Biol. 2019 Aug 28;64(17):175005. doi: 10.1088/1361-6560/ab314c.
PMID: 31295730
Assessing the interactions between radiotherapy and antitumour immunity.
Grassberger C, Ellsworth SG, Wilks MQ, Keane FK, Loeffler JS.
Nat Rev Clin Oncol. 2019 Dec;16(12):729-745. doi: 10.1038/s41571-019-0238-9. Epub 2019 Jun 26.
PMID: 31243334 Review.
Modulation of gold nanoparticle mediated radiation dose enhancement through synchronization of breast tumor cell population.
Rieck K, Bromma K, Sung W, Bannister A, Schuemann J, Chithrani DB.
Br J Radiol. 2019 Aug;92(1100):20190283. doi: 10.1259/bjr.20190283. Epub 2019 Jul 2.
PMID: 31219711 Free PMC article.
Validation of a model for physical dose variations in irregularly moving targets treated with carbon ion beams.
Meschini G, Seregni M, Molinelli S, Vai A, Phillips J, Sharp GC, Pella A, Valvo F, Ciocca M, Riboldi M, Paganetti H, Baroni G.
Med Phys. 2019 Aug;46(8):3663-3673. doi: 10.1002/mp.13662. Epub 2019 Jul 8.
PMID: 31206718
The microdosimetric extension in TOPAS: development and comparison with published data.
Zhu H, Chen Y, Sung W, McNamara AL, Tran LT, Burigo LN, Rosenfeld AB, Li J, Faddegon B, Schuemann J, Paganetti H.
Phys Med Biol. 2019 Jul 11;64(14):145004. doi: 10.1088/1361-6560/ab23a3.
PMID: 31117056 Free PMC article.
Patient-Specific Tumor Growth Trajectories Determine Persistent and Resistant Cancer Cell Populations during Treatment with Targeted Therapies.
Grassberger C, McClatchy D 3rd, Geng C, Kamran SC, Fintelmann F, Maruvka YE, Piotrowska Z, Willers H, Sequist LV, Hata AN, Paganetti H.
Cancer Res. 2019 Jul 15;79(14):3776-3788. doi: 10.1158/0008-5472.CAN-18-3652. Epub 2019 May 21.
PMID: 31113818 Free PMC article.
Applying a variable relative biological effectiveness (RBE) might affect the analysis of clinical trials comparing photon and proton therapy for prostate cancer.
Marteinsdottir M, Paganetti H.
Phys Med Biol. 2019 Jun 5;64(11):115027. doi: 10.1088/1361-6560/ab2144.
PMID: 31082810
Differential inflammatory response dynamics in normal lung following stereotactic body radiation therapy with protons versus photons.
Li Y, Dykstra M, Best TD, Pursley J, Chopra N, Keane FK, Khandekar MJ, Sharp GC, Paganetti H, Willers H, Fintelmann FJ, Grassberger C.
Radiother Oncol. 2019 Jul;136:169-175. doi: 10.1016/j.radonc.2019.04.004. Epub 2019 Apr 20.
PMID: 31015121 Free PMC article.
Predicting In Vitro Cancer Cell Survival Based on Measurable Cell Characteristics.
Oesten H, Neubeck CV, Jakob A, Enghardt W, Krause M, McMahon SJ, Grassberger C, Paganetti H, Lühr A.
Radiat Res. 2019 Jun;191(6):532-544. doi: 10.1667/RR15265.1. Epub 2019 Apr 22.
PMID: 31008688
Protons versus Photons for Unresectable Hepatocellular Carcinoma: Liver Decompensation and Overall Survival.
Sanford NN, Pursley J, Noe B, Yeap BY, Goyal L, Clark JW, Allen JN, Blaszkowsky LS, Ryan DP, Ferrone CR, Tanabe KK, Qadan M, Crane CH, Koay EJ, Eyler C, DeLaney TF, Zhu AX, Wo JY, Grassberger C, Hong TS.
Int J Radiat Oncol Biol Phys. 2019 Sep 1;105(1):64-72. doi: 10.1016/j.ijrobp.2019.01.076. Epub 2019 Jan 23.
PMID: 30684667
Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy.
Paganetti H, Blakely E, Carabe-Fernandez A, Carlson DJ, Das IJ, Dong L, Grosshans D, Held KD, Mohan R, Moiseenko V, Niemierko A, Stewart RD, Willers H.
Med Phys. 2019 Mar;46(3):e53-e78. doi: 10.1002/mp.13390. Epub 2019 Feb 14.
PMID: 30661238 Free PMC article.
TOPAS-nBio: An Extension to the TOPAS Simulation Toolkit for Cellular and Sub-cellular Radiobiology.
Schuemann J, McNamara AL, Ramos-Méndez J, Perl J, Held KD, Paganetti H, Incerti S, Faddegon B.
Radiat Res. 2019 Feb;191(2):125-138. doi: 10.1667/RR15226.1. Epub 2019 Jan 4.
PMID: 30609382 Free PMC article.
Online adaption approaches for intensity modulated proton therapy for head and neck patients based on cone beam CTs and Monte Carlo simulations.
Botas P, Kim J, Winey B, Paganetti H.
Phys Med Biol. 2018 Dec 19;64(1):015004. doi: 10.1088/1361-6560/aaf30b.
PMID: 30524097
Report of a National Cancer Institute special panel: Characterization of the physical parameters of particle beams for biological research.
Durante M, Paganetti H, Pompos A, Kry SF, Wu X, Grosshans DR.
Med Phys. 2019 Feb;46(2):e37-e52. doi: 10.1002/mp.13324. Epub 2018 Dec 31.
PMID: 30506898
Computational models and tools.
Schuemann J, Bassler N, Inaniwa T.
Med Phys. 2018 Nov;45(11):e1073-e1085. doi: 10.1002/mp.12521.
PMID: 30421814 Review.
LET-weighted doses effectively reduce biological variability in proton radiotherapy planning.
McMahon SJ, Paganetti H, Prise KM.
Phys Med Biol. 2018 Nov 9;63(22):225009. doi: 10.1088/1361-6560/aae8a5.
PMID: 30412471
A New Standard DNA Damage (SDD) Data Format.
Schuemann J, McNamara AL, Warmenhoven JW, Henthorn NT, Kirkby KJ, Merchant MJ, Ingram S, Paganetti H, Held KD, Ramos-Mendez J, Faddegon B, Perl J, Goodhead DT, Plante I, Rabus H, Nettelbeck H, Friedland W, Kundrát P, Ottolenghi A, Baiocco G, Barbieri S, Dingfelder M, Incerti S, Villagrasa C, Bueno M, Bernal MA, Guatelli S, Sakata D, Brown JMC, Francis Z, Kyriakou I, Lampe N, Ballarini F, Carante MP, Davídková M, Štěpán V, Jia X, Cucinotta FA, Schulte R, Stewart RD, Carlson DJ, Galer S, Kuncic Z, Lacombe S, Milligan J, Cho SH, Sawakuchi G, Inaniwa T, Sato T, Li W, Solov’yov AV, Surdutovich E, Durante M, Prise KM, McMahon SJ.
Radiat Res. 2019 Jan;191(1):76-92. doi: 10.1667/RR15209.1. Epub 2018 Nov 8.
PMID: 30407901 Free PMC article.
Pretreatment plasma HGF as potential biomarker for susceptibility to radiation-induced liver dysfunction after radiotherapy.
Hong TS, Grassberger C, Yeap BY, Jiang W, Wo JY, Goyal L, Clark JW, Crane CH, Koay EJ, Dima S, Eyler CE, Popescu I, DeLaney TF, Zhu AX, Duda DG.
NPJ Precis Oncol. 2018 Oct 18;2:22. doi: 10.1038/s41698-018-0065-y. eCollection 2018.
PMID: 30374460 Free PMC article.
Proton Relative Biological Effectiveness – Uncertainties and Opportunities.
Paganetti H.
Int J Part Ther. 2018 Summer;5(1):2-14. doi: 10.14338/IJPT-18-00011.1. Epub 2018 Sep 21.
PMID: 30370315 Free PMC article.
Validation of Effective Dose as a Better Predictor of Radiation Pneumonitis Risk Than Mean Lung Dose: Secondary Analysis of a Randomized Trial.
Tucker SL, Xu T, Paganetti H, Deist T, Verma V, Choi N, Mohan R, Liao Z.
Int J Radiat Oncol Biol Phys. 2019 Feb 1;103(2):403-410. doi: 10.1016/j.ijrobp.2018.09.029. Epub 2018 Oct 3.
PMID: 30291994 Clinical Trial.
Impact of potentially variable RBE in liver proton therapy.
Chen Y, Grassberger C, Li J, Hong TS, Paganetti H.
Phys Med Biol. 2018 Sep 21;63(19):195001. doi: 10.1088/1361-6560/aadf24.
PMID: 30183674 Free PMC article.
Computational Modeling and Clonogenic Assay for Radioenhancement of Gold Nanoparticles Using 3D Live Cell Images.
Sung W, Jeong Y, Kim H, Jeong H, Grassberger C, Jung S, Ahn GO, Kim IH, Schuemann J, Lee K, Ye SJ.
Radiat Res. 2018 Nov;190(5):558-564. doi: 10.1667/RR15134.1. Epub 2018 Aug 24.
PMID: 30142031 Free PMC article.
Author Correction: Prediction of Treatment Response for Combined Chemo- and Radiation Therapy for Non-Small Cell Lung Cancer Patients Using a Bio-Mathematical Model.
Geng C, Paganetti H, Grassberger C.
Sci Rep. 2018 Aug 17;8(1):12631. doi: 10.1038/s41598-018-30761-7.
PMID: 30115991 Free PMC article.
Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit.
McNamara AL, Ramos-Méndez J, Perl J, Held K, Dominguez N, Moreno E, Henthorn NT, Kirkby KJ, Meylan S, Villagrasa C, Incerti S, Faddegon B, Paganetti H, Schuemann J.
Phys Med Biol. 2018 Sep 6;63(17):175018. doi: 10.1088/1361-6560/aad8eb.
PMID: 30088810 Free PMC article.
Asymptomatic Late-phase Radiographic Changes Among Chest-Wall Patients Are Associated With a Proton RBE Exceeding 1.1.
Underwood TSA, Grassberger C, Bass R, MacDonald SM, Meyersohn NM, Yeap BY, Jimenez RB, Paganetti H.
Int J Radiat Oncol Biol Phys. 2018 Jul 15;101(4):809-819. doi: 10.1016/j.ijrobp.2018.03.037. Epub 2018 Apr 17.
PMID: 29976493
Relative Biological Effectiveness Uncertainties and Implications for Beam Arrangements and Dose Constraints in Proton Therapy.
Paganetti H, Giantsoudi D.
Semin Radiat Oncol. 2018 Jun;28(3):256-263. doi: 10.1016/j.semradonc.2018.02.010.
PMID: 29933885 Review.
Considerations when treating lung cancer with passive scatter or active scanning proton therapy.
St James S, Grassberger C, Lu HM.
Transl Lung Cancer Res. 2018 Apr;7(2):210-215. doi: 10.21037/tlcr.2018.04.01.
PMID: 29876321 Free PMC article. Review.
Energy optimization in gold nanoparticle enhanced radiation therapy.
Sung W, Schuemann J.
Phys Med Biol. 2018 Jun 25;63(13):135001. doi: 10.1088/1361-6560/aacab6.
PMID: 29873303 Free PMC article.
Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer.
Grassberger C, Hong TS, Hato T, Yeap BY, Wo JY, Tracy M, Bortfeld T, Wolfgang JA, Eyler CE, Goyal L, Clark JW, Crane CH, Koay EJ, Cobbold M, DeLaney TF, Jain RK, Zhu AX, Duda DG.
Int J Radiat Oncol Biol Phys. 2018 Aug 1;101(5):1222-1225. doi: 10.1016/j.ijrobp.2018.04.026. Epub 2018 Apr 17.
PMID: 29859792 Free PMC article. Clinical Trial.
Determining the Radiation Enhancement Effects of Gold Nanoparticles in Cells in a Combined Treatment with Cisplatin and Radiation at Therapeutic Megavoltage Energies.
Yang C, Bromma K, Sung W, Schuemann J, Chithrani D.
Cancers (Basel). 2018 May 22;10(5):150. doi: 10.3390/cancers10050150.
PMID: 29786642 Free PMC article.
Robust Proton Treatment Planning: Physical and Biological Optimization.
Unkelbach J, Paganetti H.
Semin Radiat Oncol. 2018 Apr;28(2):88-96. doi: 10.1016/j.semradonc.2017.11.005.
PMID: 29735195 Free PMC article. Review.
Can differences in linear energy transfer and thus relative biological effectiveness compromise the dosimetric advantage of intensity-modulated proton therapy as compared to passively scattered proton therapy?
Giantsoudi D, Adams J, MacDonald S, Paganetti H.
Acta Oncol. 2018 Sep;57(9):1259-1264. doi: 10.1080/0284186X.2018.1468090. Epub 2018 May 4.
PMID: 29726722 Clinical Trial.
Monte Carlo simulation of chemistry following radiolysis with TOPAS-nBio.
Ramos-Méndez J, Perl J, Schuemann J, McNamara A, Paganetti H, Faddegon B.
Phys Med Biol. 2018 May 17;63(10):105014. doi: 10.1088/1361-6560/aac04c.
PMID: 29697057 Free PMC article.
National Cancer Institute Workshop on Proton Therapy for Children: Considerations Regarding Brainstem Injury.
Haas-Kogan D, Indelicato D, Paganetti H, Esiashvili N, Mahajan A, Yock T, Flampouri S, MacDonald S, Fouladi M, Stephen K, Kalapurakal J, Terezakis S, Kooy H, Grosshans D, Makrigiorgos M, Mishra K, Poussaint TY, Cohen K, Fitzgerald T, Gondi V, Liu A, Michalski J, Mirkovic D, Mohan R, Perkins S, Wong K, Vikram B, Buchsbaum J, Kun L.
Int J Radiat Oncol Biol Phys. 2018 May 1;101(1):152-168. doi: 10.1016/j.ijrobp.2018.01.013.
PMID: 29619963 Free PMC article. Review.
Brainstem Injury in Pediatric Patients With Posterior Fossa Tumors Treated With Proton Beam Therapy and Associated Dosimetric Factors.
Gentile MS, Yeap BY, Paganetti H, Goebel CP, Gaudet DE, Gallotto SL, Weyman EA, Morgan ML, MacDonald SM, Giantsoudi D, Adams J, Tarbell NJ, Kooy H, Yock TI.
Int J Radiat Oncol Biol Phys. 2018 Mar 1;100(3):719-729. doi: 10.1016/j.ijrobp.2017.11.026. Epub 2017 Nov 23.
PMID: 29413284
Density overwrites of internal tumor volumes in intensity modulated proton therapy plans for mobile lung tumors.
Botas P, Grassberger C, Sharp G, Paganetti H.
Phys Med Biol. 2018 Jan 30;63(3):035023. doi: 10.1088/1361-6560/aaa035.
PMID: 29219119 Free PMC article.